PXD055553

PXD055553 is an original dataset announced via ProteomeXchange.

Title	The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi
Description	We quantified the proteome of Dsc complex mutants (tul1gld1) and ESCRT mutants (vps4). Therefore we used stable isotope labeling with amino acids in cell culture (SILAC) to identify changes in the membrane proteome of tul1gld1orvps4 cells relative to WT cells or gld1 cells (labeled with “heavy” [13C6,15N2]-L-lysine).
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_03:31:30.070.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Leopold Kremser
SpeciesList	scientific name: Candida albicans (Yeast); NCBI TaxID: 5476;
ModificationList	6x(13)C labeled residue
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-04 09:32:51	ID requested
⏵ 1	2025-05-07 03:31:30	announced

10.1038/s41467-024-53676-6;

Weyer Y, Schwabl SI, Tang X, Purwar A, Siegmann K, Ruepp A, Dunzendorfer-Matt T, Widerin MA, Niedrist V, Mutsters NJM, Tettamanti MG, Weys S, Sarg B, Kremser L, Liedl KR, Schmidt O, Teis D, The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi. Nat Commun, 15(1):9257(2024) [pubmed]

submitter keyword: degron, Dsc complex, quality control, ESCRT,Golgi, lipids, ubiquitin

David Teis
contact affiliation	Institute of Molecular Biochemistry, Medical Univeristy of Innsbruck, Austria
contact email	david.teis@i-med.ac.at
lab head
Leopold Kremser
contact affiliation	Medical University Innsbruck
contact email	Leopold.Kremser@i-med.ac.at
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD055553

PRIDE project URI

• PRIDE
  1. PXD055553
     1. Label: PRIDE project
     2. Name: The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi