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PXD055527

PXD055527 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSpatiotemporal Proteomic and Transcriptomic Landscape of DAT+ Dopaminergic Neurons Development and Function
DescriptionDopaminergic (DA) neurons marked by the dopamine transporter (DAT) have multiple physiological functions and are involved in the regulation of mental and neurological diseases, prompting in-depth studies into their development and functions. This research explores the spatiotemporal proteomic and transcriptomic changes in DAT+ DA neurons within key brain regions involved in DA signaling—the nucleus accumbens (NAc), substantia nigra (SNc), and ventral tegmental area (VTA). Utilizing cutting-edge multi-omics techniques, such as ultrasensitive trace sample proteomics and SMART-seq2 for transcriptomics, we examine the DA neuronal system at critical postnatal milestones: postnatal day 7 (P7), postnatal day 30 (P30), and postnatal day 60 (P60). The study reveals unique molecular profiles within DA neuron populations, showcasing their varied functional roles and developmental progression.
HostingRepositoryiProX
AnnounceDate2024-09-03
AnnouncementXMLSubmission_2024-09-03_20:03:13.908.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHeyu Zhao
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-09-03 20:01:20ID requested
12024-09-03 20:03:14announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Brain region, DAT+ Dopaminergic Neurons, Proteomics, Transcriptomics, Aldh1a1, Neuron development
Contact List
Huali Shen
contact affiliationFudan University
contact emailshenhuali@fudan.edu.cn
lab head
Heyu Zhao
contact affiliationFudan University
contact emailzhaohy16@fudan.edu.cn
dataset submitter
Full Dataset Link List
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