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PXD055495

PXD055495 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Lenalidomide-induced pure red cell aplasia analysis
Description	The RVd therapy, combining lenalidomide, bortezomib, and dexamethasone, is a mainstay treatment for multiple myeloma. A multiple myeloma patient developed pure red cell aplasia (PRCA) following RVd treatment, despite the absence of common PRCA triggers. In vitro analyses revealed lenalidomide as a pivotal disruptor of erythropoiesis. Single-cell transcriptome analysis unveiled hyperactive CD8+ T cells and impaired erythropoiesis in the patient's bone marrow. Unexpectedly, the patient's erythroid cells displayed abnormally high expression of genes in the antigen presentation pathway, particularly those for major histocompatibility class I (MHC-I) molecules. Functional assays demonstrated that lenalidomide treatment further augmented MHC-I expression in the patient's erythroid cells. Blocking MHC-I or depleting T cells alleviate the defective erythropoiesis of PRCA, suggesting that the interaction between erythroid cells with elevated MHC-I and T cells in the bone marrow might contribute to PRCA. Taken together, our study revealed a novel mechanism underlying lenalidomide-induced PRCA in treating cancer patients.
HostingRepository	iProX
AnnounceDate	2024-09-03
AnnouncementXML	Submission_2024-09-02_20:31:07.438.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Qi Hu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-02 20:30:57	ID requested
⏵ 1	2024-09-02 20:31:07	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: MHC-I, PRCA

Contact List

Hsiang-Ying Lee
contact affiliation	Peking University
contact email	slee@pku.edu.cn
lab head
Qi Hu
contact affiliation	Peking University
contact email	molinta1124@163.com
dataset submitter

Full Dataset Link List

iProX dataset URI