PXD055494
PXD055494 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Effect of WS974536 on astrocyte proteomics |
| Description | Astrocyte-derived L-serine was found to regulate interstitial D-serine levels and seizure activity in a process controlled by phosphoserine phosphatase (PSPH). We identified a potent PSPH inhibitor, WS974536,nd found that its systemic administration dramatically reduced the frequency of spontaneous epileptic discharges in mouse and cynomolgus monkey models of TLE. In the project. We studied the effect of WS974536 on astrocytes by proteomics. |
| HostingRepository | iProX |
| AnnounceDate | 2024-09-03 |
| AnnouncementXML | Submission_2024-09-02_20:27:34.817.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yanbing Wang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-09-02 20:26:45 | ID requested | |
| ⏵ 1 | 2024-09-02 20:27:35 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Temporal lobe epilepsy, WS974536, PSPH, serine, proteomics |
Contact List
| Xu Qi | |
|---|---|
| contact affiliation | Chinese Academy of Medical Sciences and Peking Union Medical College |
| contact email | xuqi@pumc.edu.cn |
| lab head | |
| Yanbing Wang | |
| contact affiliation | Chinese Academy of Medical Sciences and Peking Union Medical College |
| contact email | w18634306858@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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