PXD055479 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Exploring the interactome of Miro2 in hippocampal neural stem cells through TurboID-mediated proximity labeling |
| Description | Mitochondrial Rho-GTPase (Miro), a protein found on the outer mitochondrial membrane, is required for mitochondrial transport, mitochondrial dynamics, and mitochondrial Ca2+ homeostasis. We previously reported that Miro2 plays a role in the survival of hippocampal neural stem (HCN) cells, with effects on mitochondrial morphology and function. Furthermore, we revealed that Miro2 expression level is associated with neurodegeneration in animal models of Alzheimer's disease and patients with dementia. Nevertheless, a comprehensive investigation is still needed; thus, we analyzed the interacting proteins of Miro2 to elucidate its mechanisms in HCN cells by employing TurboID-based proximity labeling. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-23 |
| AnnouncementXML | Submission_2026-02-22_16:58:20.659.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD055479 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Chulhwan (Sean) Kwak |
| SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116; |
| ModificationList | biotinylated residue; acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-09-02 12:26:20 | ID requested | |
| ⏵ 1 | 2026-02-22 16:58:21 | announced | |
Publication List
| 10.1038/s42003-025-08990-0; |
| 10.6019/PXD055479; |
| Kang IK, Lee S, Moon TK, Han AR, Yu DB, Jung M, Kwak C, Seo JK, Rhee HW, Kim SW, Woo HN, Mun JY, Lee H, Proximity labeling unveils potential roles of the Miro2-CISD1 network in mitochondrial dynamics and neuronal differentiation. Commun Biol, 9(1):195(2026) [pubmed] |
Keyword List
| ProteomeXchange project tag: Human Proteome Project, Bioinformatics Infrastructure for Life Sciences (BILS) network (Sweden), Mitochondria (HPP) |
| submitter keyword: Proximity labeling, TurboID,Rattus norvegicus, RHOT2, LC/MS-MS, hippocampal neural stem cell |
Contact List
| Heuiran Lee |
|---|
| contact affiliation | Department of Microbiology, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea |
| contact email | heuiran@amc.seoul.kr |
| lab head | |
| Chulhwan (Sean) Kwak |
|---|
| contact affiliation | Stanford university |
| contact email | seanckwak@stanford.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD055479
- Label: PRIDE project
- Name: Exploring the interactome of Miro2 in hippocampal neural stem cells through TurboID-mediated proximity labeling
