<<< Full experiment listing

PXD055452

PXD055452 is an original dataset announced via ProteomeXchange.

Dataset Summary
Title4D-DIA-based quantitative proteomic analysis reveals the involvement of TRPV2 protein in duck Tembusu virus replication
DescriptionUsing a quantitative proteomics approach based on 4D-DIA combined with LC-MS/MS analysis, we identified TRPV2 as a potential host resistance factor that was significantly upregulated in DF-1 cells 48 hours post-DTMUV infection. Further experiments involving siRNA-mediated knockdown of TRPV2 expression in DF-1 cells revealed that suppression of TRPV2 expression inhibited DTMUV replication within the cells. Therefore, TRPV2 emerges as a promising candidate for poultry breeding programs aimed at enhancing resistance against DTMUV infection, serving as a potential target for the development of DTMUV-resistant animals in avian breeding.
HostingRepositoryiProX
AnnounceDate2024-09-01
AnnouncementXMLSubmission_2024-09-01_22:43:17.815.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHuihuang Li
SpeciesList scientific name: Gallus gallus; NCBI TaxID: 9031;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-09-01 22:41:28ID requested
12024-09-01 22:43:18announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Duck Tembusu virus, Quantitative proteomics, DF-1 cells, TRPV2
Contact List
Ruiyi Lin
contact affiliationFujian Agriculture and Forest University College of Animal Science
contact emaillinruiyi@fafu.edu.cn
lab head
Huihuang Li
contact affiliationFujian Agriculture and Forest University College of Animal Science
contact emaillihuihuang@fafu.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI