PXD055443
PXD055443 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Integrated proteomics and metabolomics reveal the mechanisms of blood pressure reduction in spontaneously hypertensive rats under high altitude hypoxic conditions |
| Description | In this study, we employed an integrated proteomic and metabolomic approach to systematically analyze the proteome and metabolome profiles of SHRs following prolonged exposure to a high-altitude hypoxic environment. Bioinformatics and enrichment analysis revealed that proteins with significant differential expression were predominantly involved in pathways such as oxidative phosphorylation, thermogenesis, TCA cycle, and carbon metabolism. Further analysis indicated that alterations in key metabolites, including thiamine, S-adenosylhomocysteine, pantothenic acid, fumaric acid, and homoserine, interact with differentially expressed proteins, collectively contributing to the modulation of blood pressure regulation in SHRs under hypoxic conditions. This research provides new molecular insights into understanding the impact of high-altitude hypoxia on the blood pressure regulatory mechanisms in spontaneously hypertensive rats. |
| HostingRepository | iProX |
| AnnounceDate | 2024-08-27 |
| AnnouncementXML | Submission_2024-09-01_20:12:35.712.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Delong Duo |
| SpeciesList | scientific name: Rattus norvegicus; NCBI TaxID: 10116; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-09-01 20:11:30 | ID requested | |
| ⏵ 1 | 2024-09-01 20:12:36 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: high-altitude hypoxia, blood pressure, spontaneously hypertensive rats, proteomics, metabolomics |
Contact List
| Xiangyang Li | |
|---|---|
| contact affiliation | Qinghai University |
| contact email | qhmclxy@163.com |
| lab head | |
| Delong Duo | |
| contact affiliation | Research Center for High-altitude Medicine, Qinghai University Medical College |
| contact email | duodelong12@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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