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PXD055443

PXD055443 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIntegrated proteomics and metabolomics reveal the mechanisms of blood pressure reduction in spontaneously hypertensive rats under high altitude hypoxic conditions
DescriptionIn this study, we employed an integrated proteomic and metabolomic approach to systematically analyze the proteome and metabolome profiles of SHRs following prolonged exposure to a high-altitude hypoxic environment. Bioinformatics and enrichment analysis revealed that proteins with significant differential expression were predominantly involved in pathways such as oxidative phosphorylation, thermogenesis, TCA cycle, and carbon metabolism. Further analysis indicated that alterations in key metabolites, including thiamine, S-adenosylhomocysteine, pantothenic acid, fumaric acid, and homoserine, interact with differentially expressed proteins, collectively contributing to the modulation of blood pressure regulation in SHRs under hypoxic conditions. This research provides new molecular insights into understanding the impact of high-altitude hypoxia on the blood pressure regulatory mechanisms in spontaneously hypertensive rats.
HostingRepositoryiProX
AnnounceDate2024-08-27
AnnouncementXMLSubmission_2024-09-01_20:12:35.712.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDelong Duo
SpeciesList scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-09-01 20:11:30ID requested
12024-09-01 20:12:36announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: high-altitude hypoxia, blood pressure, spontaneously hypertensive rats, proteomics, metabolomics
Contact List
Xiangyang Li
contact affiliationQinghai University
contact emailqhmclxy@163.com
lab head
Delong Duo
contact affiliationResearch Center for High-altitude Medicine, Qinghai University Medical College
contact emailduodelong12@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI