PXD055430

PXD055430 is an original dataset announced via ProteomeXchange.

Title	Proteomic Comparison Between Hyphae and Spores Reveals Pathogenicity Diversity in Mucor Irregularis
Description	Mucor irregularis poses significant clinical risks, including severe disfigurement, with hyphal forms being more commonly encountered in clinical settings compared to spore forms. However, the pathogenic differences between these forms at the protein level remain poorly understood. This study employed TMT-based quantitative proteomics to investigate the proteomic differences between spores and hyphae of Mucor irregularis. Our analysis revealed that differentially abundant proteins are predominantly expressed during the hyphal stage. Notably, key enzymes such as RhoGEF GTPase, Subtilisin-related Protease, Acyl-CoA Synthetase, and Ribonuclease T2 appear crucial for hyphal morphological development and pathogenic mechanisms. Additionally, myosins play a significant role not only in hyphal growth and virulence but also in influencing sensitivity to antifungal agents. These findings provide new insights into the morphogenesis, development, and metabolic processes of Mucor irregularis, laying a foundation for further research into its pathogenic mechanisms.
HostingRepository	PRIDE
AnnounceDate	2025-07-28
AnnouncementXML	Submission_2025-07-27_16:05:20.869.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xianliang Ma
SpeciesList	scientific name: Mucor irregularis B50; NCBI TaxID: 1290454;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-01 19:29:43	ID requested
⏵ 1	2025-07-27 16:05:21	announced

10.1021/acs.jproteome.5c00214;

Zhang M, Zhou X, Zhang Y, Song G, Li X, Liu W, Liang G, . J Proteome Res, 24(8):4060-4069(2025) [pubmed]

submitter keyword: Pathogenicity Diversity,proteomics， Mucor Irregularis

Guanzhao Liang
contact affiliation	Department of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, 210042, China
contact email	guanzhaoguan@126.com
lab head
Xianliang Ma
contact affiliation	Micrometer Biotech
contact email	maxianliangyxz@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD055430

PRIDE project URI

• PRIDE
  1. PXD055430
     1. Label: PRIDE project
     2. Name: Proteomic Comparison Between Hyphae and Spores Reveals Pathogenicity Diversity in Mucor Irregularis