PXD055419
PXD055419 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Overexpression of Initiator Methionine tRNA Suppresses Cancer Malignancy via Energy Depletion |
| Description | Translation is an essential process for all living cell types, and translation dysregulation is a common feature in cancer cells that maintain the malignacy. tRNA-iMet is essential for initiation of translation, and tRNA-iMet was considered a cancer-promoting molecular factor, as elevated tRNA-iMet levels could enhance the vigorous translation and acceralate growth of cancers. Currently, the mainstream strategies of targeting therapies for cancer theatment are to target specific alterations of oncogenes or oncoproteins invoved in certain cancer pathways, however, the adquired resistance to these treatments seem to be inevitable. There is few research explored what happens if further elevate the expression of oncogenes, based on the philosophy saying ”No Extreme will Hold Long”. In this study, we exhibite that overexpression of tRNA-iMet could inhibite growth of multiple types of cancers via energy depletion. This stratege proposed by this study displays a potential and promising option of cancer treatmen for clinical translation. |
| HostingRepository | iProX |
| AnnounceDate | 2024-08-28 |
| AnnouncementXML | Submission_2024-09-09_19:31:52.396.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jin Ma |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-09-01 18:59:43 | ID requested | |
| ⏵ 1 | 2024-09-09 19:31:52 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: tRNA-iMet,overexpression,inhibit cancers,energy depletion; |
Contact List
| Gong Zhang | |
|---|---|
| contact affiliation | Jinan University |
| contact email | zhanggong-uni@qq.com |
| lab head | |
| Jin Ma | |
| contact affiliation | Jinan University |
| contact email | majin.edu@outlook.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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