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PXD055317

PXD055317 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Estrogen inhibits the progression of liver cancer by modulating PRDX-induced ferroptosis
Description	Liver cancer exhibits significant gender disparities, with men having a 2-5 times higher risk of developing liver cancer compared to women. Numerous studies have demonstrated the influence of estrogen on liver cancer development, although the precise underlying mechanism remains unclear. Peroxiredoxins (PRDXs) represent a recently identified peroxidase family that modulates various signaling pathways associated with reactive oxygen species. This research aims to explore the impact of estrogen on the expression of PRDX1, PRDX5, and PRDX6 in hepatocellular carcinoma cells, thereby modulating liver cancer progression. Treatment with estrogen and the silencing of PRDX1, PRDX5, and PRDX6 impairs the proliferative capacity of hepatocarcinoma cells. The levels of PRDX1, PRDX5, and PRDX6 were found to be elevated in hepatocellular carcinoma compared to normal tissues, with estrogen demonstrating the ability to decrease their expression in hepatocellular carcinoma cells. Furthermore, estrogen influences the expression of PRDXs (PRDX5 and PRDX6) by regulating RASA1. Additionally, estrogen stimulation impacts ferroptosis in hepatocellular carcinoma cells, suggesting that PRDXs and ferroptosis-related genes are estrogen-responsive genes that promote liver cancer progression. Elevated LPCAT3 levels and downregulation of PRDX1, PRDX5, and PRDX6 expression may potentially manage the advancement of HCC.
HostingRepository	iProX
AnnounceDate	2024-08-26
AnnouncementXML	Submission_2024-08-28_20:32:36.128.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chunhua Liu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-28 20:32:26	ID requested
⏵ 1	2024-08-28 20:32:36	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: PRDX

Contact List

Chunhua Liu
contact affiliation	Shandong First Medical University
contact email	mimigirl669@163.com
lab head
Chunhua Liu
contact affiliation	Shandong First Medical University
contact email	mimigirl669@163.com
dataset submitter

Full Dataset Link List

iProX dataset URI