<<< Full experiment listing

PXD055317

PXD055317 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleEstrogen inhibits the progression of liver cancer by modulating PRDX-induced ferroptosis
DescriptionLiver cancer exhibits significant gender disparities, with men having a 2-5 times higher risk of developing liver cancer compared to women. Numerous studies have demonstrated the influence of estrogen on liver cancer development, although the precise underlying mechanism remains unclear. Peroxiredoxins (PRDXs) represent a recently identified peroxidase family that modulates various signaling pathways associated with reactive oxygen species. This research aims to explore the impact of estrogen on the expression of PRDX1, PRDX5, and PRDX6 in hepatocellular carcinoma cells, thereby modulating liver cancer progression. Treatment with estrogen and the silencing of PRDX1, PRDX5, and PRDX6 impairs the proliferative capacity of hepatocarcinoma cells. The levels of PRDX1, PRDX5, and PRDX6 were found to be elevated in hepatocellular carcinoma compared to normal tissues, with estrogen demonstrating the ability to decrease their expression in hepatocellular carcinoma cells. Furthermore, estrogen influences the expression of PRDXs (PRDX5 and PRDX6) by regulating RASA1. Additionally, estrogen stimulation impacts ferroptosis in hepatocellular carcinoma cells, suggesting that PRDXs and ferroptosis-related genes are estrogen-responsive genes that promote liver cancer progression. Elevated LPCAT3 levels and downregulation of PRDX1, PRDX5, and PRDX6 expression may potentially manage the advancement of HCC.
HostingRepositoryiProX
AnnounceDate2024-08-26
AnnouncementXMLSubmission_2024-08-28_20:32:36.128.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterChunhua Liu
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-08-28 20:32:26ID requested
12024-08-28 20:32:36announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: PRDX
Contact List
Chunhua Liu
contact affiliationShandong First Medical University
contact emailmimigirl669@163.com
lab head
Chunhua Liu
contact affiliationShandong First Medical University
contact emailmimigirl669@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI