PXD055305

PXD055305 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Comparison of MSA with PD/DLB alpha-synuclein pathology using proximity proteomics
Description	Multiple systems atrophy (MSA) is a unique synucleinopathy of unknown cause characterized by alpha-synuclein aggregates in oligodendroglia. Here, we used the in-situ proximity labeling technique biotinylation (BAR) by antibody recognition to identify alpha-synuclein interactomes in the MSA brain and compare them with other common synucleinopathies.
HostingRepository	PRIDE
AnnounceDate	2025-03-27
AnnouncementXML	Submission_2025-03-27_05:37:21.555.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bryan Killinger
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-28 17:31:09	ID requested
⏵ 1	2025-03-27 05:37:22	announced

Publication List

10.1186/s40478-025-01958-5;
Choi SG, Tittle TR, Barot RR, Betts DJ, Gallagher JJ, Kordower JH, Chu Y, Killinger BA, Proximity proteomics reveals unique and shared pathological features between multiple system atrophy and Parkinson's disease. Acta Neuropathol Commun, 13(1):65(2025) [pubmed]

10.1186/s40478-025-01958-5;

Choi SG, Tittle TR, Barot RR, Betts DJ, Gallagher JJ, Kordower JH, Chu Y, Killinger BA, Proximity proteomics reveals unique and shared pathological features between multiple system atrophy and Parkinson's disease. Acta Neuropathol Commun, 13(1):65(2025) [pubmed]

Keyword List

submitter keyword: alpha-synuclein, interactome

submitter keyword: alpha-synuclein, interactome

Contact List

Bryan Killinger
contact affiliation	Rush University Medical Center
contact email	bryan_killinger@rush.edu
lab head
Bryan Killinger
contact affiliation	Rush University Medical Center
contact email	bryan_killinger@rush.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD055305
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD055305

PRIDE project URI

Repository Record List

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