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PXD055281

PXD055281 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleRevisiting the relevance of the accumulation of apolipoprotein E (APOE) in mitochondria-associated ER membranes: Investi-gation of hepatic protein-protein interactions of APOE with LONP1, TOMM40 and VDAC1
DescriptionInvestigating the subcellular distribution and protein interaction of APOE and the modulation by cellular stress signals, we aimed to contribute to the elucidation of putative novel functions. We identified APOE as hepatic mitochondria-associated ER-membranes (MAM) protein, where it most likely interacts with the mitochondrial proteins LONP1, TOMM40 and VDAC1. We pro-pose that the interaction with TOMM40 and VDAC1 enables specific mitochondria-ER contacts with so far unknown functional relevance. However, MAM residing APOE may help in unfolded protein response possibly by co-operation with LONP1 at the interface of mitochondria and ER membranes.
HostingRepositoryPRIDE
AnnounceDate2025-05-07
AnnouncementXMLSubmission_2025-05-07_02:05:35.149.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAndreas Tholey
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-08-28 03:23:16ID requested
12025-05-07 02:05:36announced
Publication List
10.3390/ijms251910597;
Rueter J, Rimbach G, Bilke S, Tholey A, Huebbe P, Readdressing the Localization of Apolipoprotein E (APOE) in Mitochondria-Associated Endoplasmic Reticulum (ER) Membranes (MAMs): An Investigation of the Hepatic Protein-Protein Interactions of APOE with the Mitochondrial Proteins Lon Protease (LONP1), Mitochondrial Import Receptor Subunit TOM40 (TOMM40) and Voltage-Dependent Anion-Selective Channel 1 (VDAC1). Int J Mol Sci, 25(19):(2024) [pubmed]
Keyword List
submitter keyword: mitochondria-ER contacts (MERC), MAM, stress response, proteome analysis, subcellular distribution, liver, APOE4
Contact List
Andreas Tholey
contact affiliationInstitut für experimentelle Medizin Systematische Proteomics & Bioanalytik Niemannsweg 11 24105 Kiel
contact emaila.tholey@iem.uni-kiel.de
lab head
Andreas Tholey
contact affiliationSystematic Proteome Research & Bioanalytics, University of Kiel
contact emaila.tholey@iem.uni-kiel.de
dataset submitter
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Dataset FTP location
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