PXD055281 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Revisiting the relevance of the accumulation of apolipoprotein E (APOE) in mitochondria-associated ER membranes: Investi-gation of hepatic protein-protein interactions of APOE with LONP1, TOMM40 and VDAC1 |
Description | Investigating the subcellular distribution and protein interaction of APOE and the modulation by cellular stress signals, we aimed to contribute to the elucidation of putative novel functions. We identified APOE as hepatic mitochondria-associated ER-membranes (MAM) protein, where it most likely interacts with the mitochondrial proteins LONP1, TOMM40 and VDAC1. We pro-pose that the interaction with TOMM40 and VDAC1 enables specific mitochondria-ER contacts with so far unknown functional relevance. However, MAM residing APOE may help in unfolded protein response possibly by co-operation with LONP1 at the interface of mitochondria and ER membranes. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-07 |
AnnouncementXML | Submission_2025-05-07_02:05:35.149.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Andreas Tholey |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-08-28 03:23:16 | ID requested | |
⏵ 1 | 2025-05-07 02:05:36 | announced | |
Publication List
10.3390/ijms251910597; |
Rueter J, Rimbach G, Bilke S, Tholey A, Huebbe P, Readdressing the Localization of Apolipoprotein E (APOE) in Mitochondria-Associated Endoplasmic Reticulum (ER) Membranes (MAMs): An Investigation of the Hepatic Protein-Protein Interactions of APOE with the Mitochondrial Proteins Lon Protease (LONP1), Mitochondrial Import Receptor Subunit TOM40 (TOMM40) and Voltage-Dependent Anion-Selective Channel 1 (VDAC1). Int J Mol Sci, 25(19):(2024) [pubmed] |
Keyword List
submitter keyword: mitochondria-ER contacts (MERC), MAM, stress response, proteome analysis, subcellular distribution, liver, APOE4 |
Contact List
Andreas Tholey |
contact affiliation | Institut für experimentelle Medizin Systematische Proteomics & Bioanalytik Niemannsweg 11 24105 Kiel |
contact email | a.tholey@iem.uni-kiel.de |
lab head | |
Andreas Tholey |
contact affiliation | Systematic Proteome Research & Bioanalytics, University of Kiel |
contact email | a.tholey@iem.uni-kiel.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD055281
- Label: PRIDE project
- Name: Revisiting the relevance of the accumulation of apolipoprotein E (APOE) in mitochondria-associated ER membranes: Investi-gation of hepatic protein-protein interactions of APOE with LONP1, TOMM40 and VDAC1