PXD055217 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Determine G6PD/PHGDH deamidation in HepG2 cells with CAD depletion or in cell cycles |
| Description | We report here that the trifunctional carbamoyl-phosphate synthase, aspartate transcarbamoylase, and dihydroorotase (CAD) activates the pentose phosphate pathway (PPP) and serine synthesis pathway (SSP) to promote de novo nucleotide synthesis via deamidation. Biochemical analyses show that CAD interacts with and deamidates glucose-6-phosphate dehydrogenase (G6PD) and phosphoglycerate dehydrogenase (PHGDH), which are rate-limiting enzymes of the PPP and SSP, respectively. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-03 |
| AnnouncementXML | Submission_2026-02-03_07:46:34.925.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Chao Qin |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | deamidated residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-08-26 19:15:11 | ID requested | |
| ⏵ 1 | 2026-02-03 07:46:35 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Liver, G6PD, PHGDH, CAD, deamidation |
Contact List
| Chao Qin |
|---|
| contact affiliation | Section of Infection and Immunity, Herman Ostrow School of Dentistry, University of Southern California |
| contact email | chaochin@usc.edu |
| lab head | |
| Chao Qin |
|---|
| contact affiliation | University of Southern California |
| contact email | chaochin@usc.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD055217
- Label: PRIDE project
- Name: Determine G6PD/PHGDH deamidation in HepG2 cells with CAD depletion or in cell cycles
