PXD055182

PXD055182 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Comprehensive proteomic analysis reveals distinct features and diagnostic biomarker panel for early pregnancy loss in histological subtypes
Description	Early pregnancy loss (EPL) is a common event in human reproduction and is classified into histological subtypes such as hydropic abortion (HA) and hydatidiform moles, including complete hydatidiform moles (CHMs) and partial hydatidiform moles (PHMs). However, accurate diagnosis and improved patient management remain challenging due to high rates of misdiagnosis and diverse prognostic risks. Therefore, diagnostic biomarkers for EPL are urgently needed. Our study aimed to identify such biomarkers through comprehensive proteomic analysis. Ten CHMs, six PHMs, ten HAs and ten normal control (NC) products of conception were uesed to obtain a proteomic portrait. Parallel reaction monitoring (PRM)-targeted proteomic and regression analyses were employed to validate and select the diagnostic signatures.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_01:54:13.395.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yating Zhao
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-25 13:15:32	ID requested
⏵ 1	2025-05-07 01:54:14	announced

Publication List

Zhao Y, Liang Y, Cai L, Cai L, Huang B, Han P, Zhang X, Zhang H, Chen Z, Yin X, Duan P, Shou H, Zhu X, Wang Z, Wan Q, Huang J, Qian J, Comprehensive Proteomic Analysis Reveals Distinct Features and a Diagnostic Biomarker Panel for Early Pregnancy Loss in Histological Subtypes. Mol Cell Proteomics, 23(11):100848(2024) [pubmed]
10.1016/j.mcpro.2024.100848;

Zhao Y, Liang Y, Cai L, Cai L, Huang B, Han P, Zhang X, Zhang H, Chen Z, Yin X, Duan P, Shou H, Zhu X, Wang Z, Wan Q, Huang J, Qian J, Comprehensive Proteomic Analysis Reveals Distinct Features and a Diagnostic Biomarker Panel for Early Pregnancy Loss in Histological Subtypes. Mol Cell Proteomics, 23(11):100848(2024) [pubmed]

10.1016/j.mcpro.2024.100848;

Keyword List

submitter keyword: Proteomic, Hydatidiform mole,Early pregnancy loss, Precious diagnosis, Biomarkers

submitter keyword: Proteomic, Hydatidiform mole,Early pregnancy loss, Precious diagnosis, Biomarkers

Contact List

Jianhua Qian
contact affiliation	The First Affiliated Hospital of Zhejiang University School of Medicine
contact email	qianjianhua@zju.edu.cn
lab head
Yating Zhao
contact affiliation	The First Affiliated Hospital, Zhejiang University School of Medicine
contact email	12018287@zju.edu.cn
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD055182
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD055182

PRIDE project URI

Repository Record List

[ + ]