PXD055131

PXD055131 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of the eutopic endometrium of patients with internal or external ademomyosis
Description	Adenomyosis is a common benign gynecological condition causing abnormal uterine bleeding, dysmenorrhea, chronic pelvic pain, as well as infertility . Histologically, adenomyosis is defined by the presence of ectopic endometrial glands and stroma surrounded by hypertrophic and hyperplastic myometrium . Recent studies have defined two distinct phenotypes of adenomyosis based on the location of adenomyotic lesions within the myometrium: either predominantly in the inner layer (internal adenomyosis) or more confined to the outer layer (external adenomyosis) . Patients with external and internal adenomyosis phenotypes present radiological and clinical-demographic differences (. Although the exact etiology of the disease remains debated, some authors suggest that internal adenomyosis results from endometrial invasion or de novo from metaplasia of embryonic or adult stem cell transformation within the myometrium, while external adenomyosis may occur through invasion from adjacent endometriotic lesions or from differentiation of endometrial stem cells deposited during retrograde menstruation. In this work we compare the protein expression profile of the endometria of patients with either internal or external adenomyosis using a DIA-based label free approach.
HostingRepository	PRIDE
AnnounceDate	2025-01-14
AnnouncementXML	Submission_2025-01-14_03:45:39.018.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mikel Azkargorta
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-23 06:20:04	ID requested
⏵ 1	2025-01-14 03:45:39	announced

Dataset with its publication pending

submitter keyword: internal, DIA, external,Adenomyosis, LC-MS/MS

Felix Elortza
contact affiliation	Proteomics Platform CIC bioGUNE Bizkaia Tech. Park Build. 800 4860 Derio (Spain)
contact email	felortza@cicbiogune.es
lab head
Mikel Azkargorta
contact affiliation	Proteomics Platform CIC bioGUNE
contact email	mazkargorta@cicbiogune.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD055131

PRIDE project URI

• PRIDE
  1. PXD055131
     1. Label: PRIDE project
     2. Name: Proteomic analysis of the eutopic endometrium of patients with internal or external ademomyosis