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PXD055083

PXD055083 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMouse female hippocampus proteomics of Alzheimer Tg-SwDI Model
DescriptionCerebral Amyloid Angiopathy (CAA) is a significant comorbidity in almost all cases of Alzheimer’s disease (AD) and is unaddressed by current treatment regimens. We explored the Tg-SwDI mouse model which expresses human Amyloid Precursor Protein with the familial Swedish AD mutation as well as the vasculotropic Dutch and Iowa mutations leading to a phenotype of cognitive deficits with severe CAA. This is the first mapping of cerebral parenchymal proteomes of this model. In a cohort of presymptomatic mice both the cortex and hippocampus proteomes were mapped in male as well as female mice. In the four proteomes profound adaptations were identified, and previous findings of an early and severe pathology in Tg-SwDI female mice are reaffirmed on the molecular level. In addition, the effectiveness of two Carbonic Anhydrase Inhibitors (CAIs), Acetazolamide and Methazolamide, in preventing the observed molecular adaptations was evaluated. These repurposed drugs broadly prevented the proteome adaptations in the Tg-SwDI mice.
HostingRepositoryPRIDE
AnnounceDate2025-05-07
AnnouncementXMLSubmission_2025-05-07_01:20:13.477.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJohan Palmfeldt
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-08-22 09:23:31ID requested
12025-05-07 01:20:14announced
Publication List
Carlsen J, Fossati S, Ø, stergaard L, Guti, é, rrez-Jim, é, nez E, Palmfeldt J, Cerebral proteome adaptations to amyloid angiopathy are prevented by carbonic anhydrase inhibitors. Alzheimers Dement, 21(4):e70122(2025) [pubmed]
10.1002/alz.70122;
Keyword List
submitter keyword: Alzheimer's,Mouse, Brain, Proteomics
Contact List
Johan Palmfeldt
contact affiliationAarhus University, Denmark
contact emailjohan.palmfeldt@clin.au.dk
lab head
Johan Palmfeldt
contact affiliationAarhus University Hospital
contact emailjohan.palmfeldt@clin.au.dk
dataset submitter
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Dataset FTP location
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