PXD055083 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mouse female hippocampus proteomics of Alzheimer Tg-SwDI Model |
Description | Cerebral Amyloid Angiopathy (CAA) is a significant comorbidity in almost all cases of Alzheimer’s disease (AD) and is unaddressed by current treatment regimens. We explored the Tg-SwDI mouse model which expresses human Amyloid Precursor Protein with the familial Swedish AD mutation as well as the vasculotropic Dutch and Iowa mutations leading to a phenotype of cognitive deficits with severe CAA. This is the first mapping of cerebral parenchymal proteomes of this model. In a cohort of presymptomatic mice both the cortex and hippocampus proteomes were mapped in male as well as female mice. In the four proteomes profound adaptations were identified, and previous findings of an early and severe pathology in Tg-SwDI female mice are reaffirmed on the molecular level. In addition, the effectiveness of two Carbonic Anhydrase Inhibitors (CAIs), Acetazolamide and Methazolamide, in preventing the observed molecular adaptations was evaluated. These repurposed drugs broadly prevented the proteome adaptations in the Tg-SwDI mice. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-07 |
AnnouncementXML | Submission_2025-05-07_01:20:13.477.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Johan Palmfeldt |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-08-22 09:23:31 | ID requested | |
⏵ 1 | 2025-05-07 01:20:14 | announced | |
Publication List
Carlsen J, Fossati S, Ø, stergaard L, Guti, é, rrez-Jim, é, nez E, Palmfeldt J, Cerebral proteome adaptations to amyloid angiopathy are prevented by carbonic anhydrase inhibitors. Alzheimers Dement, 21(4):e70122(2025) [pubmed] |
10.1002/alz.70122; |
Keyword List
submitter keyword: Alzheimer's,Mouse, Brain, Proteomics |
Contact List
Johan Palmfeldt |
contact affiliation | Aarhus University, Denmark |
contact email | johan.palmfeldt@clin.au.dk |
lab head | |
Johan Palmfeldt |
contact affiliation | Aarhus University Hospital |
contact email | johan.palmfeldt@clin.au.dk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD055083
- Label: PRIDE project
- Name: Mouse female hippocampus proteomics of Alzheimer Tg-SwDI Model