PXD055083

PXD055083 is an original dataset announced via ProteomeXchange.

Title	Mouse female hippocampus proteomics of Alzheimer Tg-SwDI Model
Description	Cerebral Amyloid Angiopathy (CAA) is a significant comorbidity in almost all cases of Alzheimer’s disease (AD) and is unaddressed by current treatment regimens. We explored the Tg-SwDI mouse model which expresses human Amyloid Precursor Protein with the familial Swedish AD mutation as well as the vasculotropic Dutch and Iowa mutations leading to a phenotype of cognitive deficits with severe CAA. This is the first mapping of cerebral parenchymal proteomes of this model. In a cohort of presymptomatic mice both the cortex and hippocampus proteomes were mapped in male as well as female mice. In the four proteomes profound adaptations were identified, and previous findings of an early and severe pathology in Tg-SwDI female mice are reaffirmed on the molecular level. In addition, the effectiveness of two Carbonic Anhydrase Inhibitors (CAIs), Acetazolamide and Methazolamide, in preventing the observed molecular adaptations was evaluated. These repurposed drugs broadly prevented the proteome adaptations in the Tg-SwDI mice.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_01:20:13.477.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Johan Palmfeldt
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-22 09:23:31	ID requested
⏵ 1	2025-05-07 01:20:14	announced

Carlsen J, Fossati S, Ø, stergaard L, Guti, é, rrez-Jim, é, nez E, Palmfeldt J, Cerebral proteome adaptations to amyloid angiopathy are prevented by carbonic anhydrase inhibitors. Alzheimers Dement, 21(4):e70122(2025) [pubmed]

10.1002/alz.70122;

submitter keyword: Alzheimer's,Mouse, Brain, Proteomics

Johan Palmfeldt
contact affiliation	Aarhus University, Denmark
contact email	johan.palmfeldt@clin.au.dk
lab head
Johan Palmfeldt
contact affiliation	Aarhus University Hospital
contact email	johan.palmfeldt@clin.au.dk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD055083
     1. Label: PRIDE project
     2. Name: Mouse female hippocampus proteomics of Alzheimer Tg-SwDI Model