PXD054959 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Additional roles of protamine kinase SRPK1 in sperm development |
| Description | In the testis, Serine/arginine protein kinase 1 (SRPK1) and isoform 2 of Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP1γ) are essential proteins involved in protamine phosphorylation and dephosphorylation, respectively, and their deregulation is linked to defective chromatin structure and male infertility. The aim of this study was to expand the knowledge on the molecular role of these phosphorylation-modulating proteins through the identification of novel partners in the testis that could support additional roles in proper testicular function. We identified the list of proteins associated with the kinase SRPK1 and the phosphatase PP1γ in adult mouse testis, pointing out additional roles of both proteins regulating essential processes for a proper sperm differentiation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-31 |
| AnnouncementXML | Submission_2026-03-31_10:06:21.681.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Marjorie Leduc |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | acetylated residue; monohydroxylated residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-08-16 05:42:37 | ID requested | |
| ⏵ 1 | 2026-03-31 10:06:22 | announced | |
Publication List
Keyword List
| submitter keyword: testis, male reproduction, phosphorylation, immunoprecipitation, spermatogenesis,SRPK1, LC-MS/MS |
Contact List
| Julie Cocquet |
|---|
| contact affiliation | Université Paris Cité, INSERM, CNRS, Institut Cochin, F-75014 Paris, France |
| contact email | julie.cocquet@inserm.fr |
| lab head | |
| Marjorie Leduc |
|---|
| contact affiliation | Plateforme protéomique 3P5, Université de Paris, Institut Cochin, INSERM, CNRS, |
| contact email | marjorie.leduc@inserm.fr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD054959 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD054959
- Label: PRIDE project
- Name: Additional roles of protamine kinase SRPK1 in sperm development
