PXD054953 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Comparative Proteomics of Tissue and Gingival Crevicular Fluid in Periodontitis |
| Description | Periodontitis is an inflammatory condition affecting periodontal tissues, such as the gingiva and alveolar bone, surrounding the teeth. However, previous research has focused on analyzing a single sample type, such as tissue, blood, or gingival crevicular fluid (GCF), which may limit the comprehensive understanding of the complex pathology of periodontitis. We conducted a proteomic analysis using liquid chromatography-mass spectrometry (LC-MS) on the periodontal tissues and GCF from patients with periodontitis. This analysis distinguished distinct proteomic signatures between the two sample types, with 3,803 proteins being identified in periodontal tissue and 910 proteins in GCF, underscoring the significant variances pertinent to periodontal health. Proteins such as S100A12, MPO, APOA1, CTSG, and PSMA1 were markedly upregulated in GCF, suggesting their potential as key markers of neutrophil activity and systemic inflammation. These findings provide profound insights into both the local and systemic pathophysiological processes underlying periodontitis, emphasizing the utility of GCF as a non-invasive medium for reflecting comprehensive disease states. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-06 |
| AnnouncementXML | Submission_2026-04-05_19:04:30.161.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jeong-hun Mok |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | carbamoylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-08-16 02:36:34 | ID requested | |
| ⏵ 1 | 2026-04-05 19:04:31 | announced | |
Publication List
| Mok JH, Hong JY, Joo M, Bang WS, Ahn DY, Yun JH, Park JM, Comparative proteomic analysis of gingival crevicular fluid and periodontal tissue: revealing clinical potential. Clin Proteomics, 23(1):(2026) [pubmed] |
| 10.1186/s12014-026-09587-3; |
Keyword List
| submitter keyword: proteomics,Periodontitis, neutrophil, GCF, systemic inflammation |
Contact List
| Jong-Moon Park |
|---|
| contact affiliation | Basilbiotech, Incheon 22002, Republic of Korea. |
| contact email | basil@basilbiotech.com |
| lab head | |
| Jeong-hun Mok |
|---|
| contact affiliation | Gachon University Gil Medical Center, Incheon, Republic of Korea |
| contact email | jeonghunmok@naver.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD054953 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD054953
- Label: PRIDE project
- Name: Comparative Proteomics of Tissue and Gingival Crevicular Fluid in Periodontitis
