PXD054939

PXD054939 is an original dataset announced via ProteomeXchange.

Title	APEX2-MCM2 proximity labeling with high-resolution quantitative mass spectrometry in ESC
Description	Through the APEX2 technique, we identified MCM2-interacting proteins associated with the replication initiation complex. After excluding proteins from the negative controls, we detected a substantial number of interacting proteins in the positive groups of both cell types. This research establishes a basis for further study on the component proteins of the conserved DNA replication initiation complex and the transient regulatory network involving its proximal proteins.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_00:36:58.275.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiaqi Zhou
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-15 13:22:59	ID requested
⏵ 1	2025-05-07 00:36:59	announced

10.3390/ijms26031020;

Yao S, Yue Z, Ye S, Liang X, Li Y, Gan H, Zhou J, Identification of MCM2-Interacting Proteins Associated with Replication Initiation Using APEX2-Based Proximity Labeling Technology. Int J Mol Sci, 26(3):(2025) [pubmed]

submitter keyword: APEX2

MCM2

DNA replication

Proximity labeling

Haiyun Gan
contact affiliation	Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
contact email	hy.gan@siat.ac.cn
lab head
Jiaqi Zhou
contact affiliation	Shenzhen Institute of Advanced Technology
contact email	jq.zhou@siat.ac.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD054939

PRIDE project URI

• PRIDE
  1. PXD054939
     1. Label: PRIDE project
     2. Name: APEX2-MCM2 proximity labeling with high-resolution quantitative mass spectrometry in ESC