PXD054930

PXD054930 is an original dataset announced via ProteomeXchange.

Title	HDX-MS analysis of TDP-43 with RNA oligonucleotides
Description	Here we perform HDX-MS analysis of RNA binding by TDP-43
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_01:15:59.369.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Antonio Calabrese
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-15 03:05:12	ID requested
⏵ 1	2025-05-07 01:16:00	announced

Minshull TC, Byrd EJ, Olejnik M, Calabrese AN, Hydrogen-Deuterium Exchange Mass Spectrometry Reveals Mechanistic Insights into RNA Oligonucleotide-Mediated Inhibition of TDP-43 Aggregation. J Am Chem Soc, 146(49):33626-33639(2024) [pubmed]

10.1021/jacs.4c11229;

submitter keyword: TDP-43, RNA, HDX-MS

Antonio Calabrese
contact affiliation	Astbury Centre for Structural Molecular Biology Faculty of Biological Sciences University of Leeds Leeds LS2 9JT United Kingdom
contact email	a.calabrese@leeds.ac.uk
lab head
Antonio Calabrese
contact affiliation	School of Molecular and Cellular Biology, University of Leeds
contact email	a.calabrese@leeds.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD054930

PRIDE project URI

• PRIDE
  1. PXD054930
     1. Label: PRIDE project
     2. Name: HDX-MS analysis of TDP-43 with RNA oligonucleotides