⮝ Full datasets listing
PXD054821
PXD054821 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Acetate enhances long-term memory in female mice by sex-, context-, and brain region–specific epigenetic and transcriptional remodeling |
| Description | Metabolic control of chromatin and gene expression is emerging as a key mechanism influencing critical neuronal functions. Here, we found that the intermediary metabolite acetate enhanced long-term memory in female mice, and this was associated with epigenetic and transcriptional remodeling in the dorsal hippocampus. Acetate-enhanced memory was driven by increased acetylation of the histone variant H2A.Z and increased expression of genes implicated in spatial learning, in the female dorsal hippocampus. The effect of acetate on dorsal hippocampal histone modifications and gene expression differed markedly between the sexes during critical windows of memory consolidation and recall, and home cage exposure to acetate without the learning and memory tasks did not recapitulate these effects. These findings elucidate a role for the metabolite acetate in regulating dorsal hippocampal chromatin and gene expression, and this work outlines the ways in which acetate exposure enhances learning and memory. Here, we have deposited the raw data for the mass spectrometry experiments in this study. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-02-24 |
| AnnouncementXML | Submission_2026-02-24_11:08:22.877.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Gabor Egervari |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Acetyl; Methyl; Dimethyl; Trimethyl |
| Instrument | Orbitrap Ascend |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-08-12 11:50:37 | ID requested | |
| ⏵ 1 | 2026-02-24 11:08:23 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: acetate, histone modifications, H2A.Z acetylation, spatial memory, dorsal hippocampus, gene expression, mouse, cortex, learning, memory, novel object location, novel object recognition, behavior |
Contact List
| Gabor Egervari | |
|---|---|
| contact affiliation | Washington University School of Medicine |
| contact email | gabor@wustl.edu |
| lab head | |
| Gabor Egervari | |
| contact affiliation | Washington University in Saint Louis |
| contact email | gabor@wustl.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v08/MSV000095573/ |
