PXD054790

PXD054790 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	The Pan-Cancer Proteome Atlas, a mass spectrometry-based landscape for understanding tumor biology and discovering biomarkers and therapeutic targets
Description	Next-generation quantitative proteomics based on data-independent acquisition mass spectrometry (DIA-MS) enables large-scale sample profiling, a necessity for (pre)clinical studies with heterogeneous samples. To date, most cancer protein profiling studies have focussed on a single cancer type. Here we report on The PanCancer Proteome Atlas (TPCPA) project, a multi-laboratory cancer proteome profiling effort based on DIA-MS. We generated a pan-cancer proteome landscape consisting of 1129 samples including 999 primary cancers representing 22 cancer types, to better understand cancer biology and to identify core and cancer type-enriched molecular therapeutic targets and biomarkers.
HostingRepository	PRIDE
AnnounceDate	2025-05-31
AnnouncementXML	Submission_2025-05-30_22:58:43.819.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thang Pham
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-11 17:06:29	ID requested
⏵ 1	2025-05-30 22:58:44	announced

Publication List

10.1016/J.CCELL.2025.05.003;

10.1016/J.CCELL.2025.05.003;

Keyword List

submitter keyword: pan-cancer proteome, DIA-MS, single shot, mass spectrometry-based proteomics

submitter keyword: pan-cancer proteome, DIA-MS, single shot, mass spectrometry-based proteomics

Contact List

Connie Jimenez
contact affiliation	Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands
contact email	c.jimenez@amsterdamumc.nl
lab head
Thang Pham
contact affiliation	Amsterdam UMC
contact email	t.pham@amsterdamumc.nl
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD054790
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD054790

PRIDE project URI

Repository Record List

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