PXD054789

PXD054789 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	GNA13 – peptide interaction analysis (GST-tag co-purification)
Description	Alpha-1-antitrypsin (AAT), a circulating serine protease inhibitor, is an acute inflammatory response protein with anti-inflammatory functions. The C-terminal peptides of AAT are found in various tissues and have been proposed as putative bioactive peptides with multiple functions, but its mechanism of action remains unclear. We previously reported that a mouse AAT C-terminal peptide of 35 amino acids (mAAT-C1-35) activates guanine nucleotide-binding protein subunit alpha 13 (Gα13). Here, we show that mAAT-C1-35 binds directly to the guanosine diphosphate (GDP)-bound form of Gα13 through the N-terminal region (mAAT-C1-17), thereby facilitating the association of Gα13・GDP with its downstream target proteins in the absence of GTP.
HostingRepository	jPOST
AnnounceDate	2025-01-01
AnnouncementXML	Submission_2025-01-05_16:27:46.131.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kosuke Ogata
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	unknown modification; L-methionine sulfoxide; S-carboxamidomethyl-L-cysteine
Instrument	Q Exactive; instrument

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-11 13:46:00	ID requested
⏵ 1	2025-01-05 16:27:46	announced

Publication List

Park Y, Matsumoto S, Ogata K, Ma B, Kanada R, Isaka Y, Arichi N, Liang X, Maki R, Kozasa T, Okuno Y, Ohno H, Ishihama Y, Toyoshima F, 13 by alpha-1-antitrypsin C-terminal peptides. J Biol Chem, 301(2):108136(2024) [pubmed]

Park Y, Matsumoto S, Ogata K, Ma B, Kanada R, Isaka Y, Arichi N, Liang X, Maki R, Kozasa T, Okuno Y, Ohno H, Ishihama Y, Toyoshima F, 13 by alpha-1-antitrypsin C-terminal peptides. J Biol Chem, 301(2):108136(2024) [pubmed]

Keyword List

submitter keyword: alpha-1-antitrypsin, guanine nucleotide-binding protein

submitter keyword: alpha-1-antitrypsin, guanine nucleotide-binding protein

Contact List

Fumiko Toyoshima
lab head
Kosuke Ogata
contact affiliation	Kyoto university
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003270/