PXD054777

PXD054777 is an original dataset announced via ProteomeXchange.

Title	INFECTION-DRIVEN PROTEOMIC SIGNATURES IN IMMUNE CELL–DERIVED EXTRACELLULAR VESICLES REFLECT HEMORRHAGIC STROKE OUTCOME
Description	Infectious complications negatively impact outcome of patients with intracerebral hemorrhage (ICH). Identification of biomarkers of the mechanisms by which infection may modify the course of stroke could help predict the clinical evolution, and the search for personalized treatments. Investigating the content of immune cell-derived extracellular vesicles (EVs), may provide relevant information in this regard. In this study we investigate the differential expression of proteins in circulating EVs from immune cells in patients with ICH according to the occurrence of infections and to outcomes. The protein content of the immune cells -derived EVs was analyzed by data independent acquisition (SWATH-MS) mass spectrometry. Differential abundance between groups was defined as fold-change ≥2 or ≤0.5 and p≤0.05.
HostingRepository	PRIDE
AnnounceDate	2026-01-26
AnnouncementXML	Submission_2026-01-25_16:25:16.136.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Susana Bravo
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-10 09:00:51	ID requested
⏵ 1	2026-01-25 16:25:17	announced

Laso-Garc, í, a F, Alonso-L, ó, pez E, Piniella D, D, í, ez-Tejedor E, G, ó, mez-de Frutos MC, Casado-Fern, á, ndez L, Otero-Ortega L, L, ó, pez-Molina MP, Gallego-Ruiz R, Pozo-Novoa J, Calzado-Gonz, á, lez Á, D, í, az-Gamero N, Rom, á, n-San Mart, í, n A, Bravo S, Barderas R, Docando F, Fuentes B, Ju, á, rez-Mart, í, n B, Alonso de Leci, ñ, ana M, Guti, é, rrez-Fern, á, ndez M, Infection-driven proteomic signatures in immune cell-derived extracellular vesicles reflect hemorrhagic stroke outcome. J Neuroinflammation, 23(1):22(2025) [pubmed]

10.1186/s12974-025-03635-9;

submitter keyword: extracellular vesicles, proteomic analysis, infection, hemorrhagic stroke

Susana B
contact affiliation	Instituto de Investigaciones Sanitarias de Santiago de Compostela
contact email	sbbravo@gmail.com
lab head
Susana Bravo
contact affiliation	FIDIS
contact email	sbbravo@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD054777

PRIDE project URI

• PRIDE
  1. PXD054777
     1. Label: PRIDE project
     2. Name: INFECTION-DRIVEN PROTEOMIC SIGNATURES IN IMMUNE CELL–DERIVED EXTRACELLULAR VESICLES REFLECT HEMORRHAGIC STROKE OUTCOME