PXD054763

PXD054763 is an original dataset announced via ProteomeXchange.

Title	Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model
Description	Impaired sleep is a common aspect of aging and often precedes the onset of Alzheimer's disease. Here, we compare the effects of sleep deprivation in young wild-type mice and their APP/PS1 littermates, a murine model of Alzheimer's disease. After 7 h of sleep deprivation, both genotypes exhibit an increase in EEG slow-wave activity. However, only the wild-type mice demonstrate an increase in the power of infraslow norepinephrine oscillations, which are characteristic of healthy non-rapid eye movement sleep. Notably, the APP/PS1 mice fail to enhance norepinephrine oscillations 24 h after sleep deprivation, coinciding with an accumulation of cerebral amyloid-β protein. Proteome analysis of cerebrospinal fluid and extracellular fluid further supports these findings by showing altered protein clearance in APP/PS1 mice. We propose that the suppression of infraslow norepinephrine oscillations following sleep deprivation contributes to increased vulnerability to sleep loss and heightens the risk of developing amyloid pathology in early stages of Alzheimer's disease.
HostingRepository	PRIDE
AnnounceDate	2025-01-30
AnnouncementXML	Submission_2025-01-30_06:00:15.180.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Niels Henning Skotte
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	reduced residue; alkylated residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-09 09:38:59	ID requested
⏵ 1	2025-01-30 06:00:16	announced

Cankar N, Beschorner N, Tsopanidou A, Qvist FL, Cola, ç, o AR, Andersen M, Kjaerby C, Delle C, Lambert M, Mundt F, Weikop P, Jucker M, Mann M, Skotte NH, Nedergaard M, accumulation in a murine Alzheimer model. Cell Rep, 43(11):114977(2024) [pubmed]

10.1016/j.celrep.2024.114977;

submitter keyword: proteomics, sleep, extracellular fluid, mouse,Cerebrospinal fluid

Niels Henning
contact affiliation	Department for Drug Design and Pharmacology, University of Copenhagen
contact email	Niels.Skotte@sund.ku.dk
lab head
Niels Henning Skotte
contact affiliation	University of Copenhagen
contact email	niels.skotte@sund.ku.dk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD054763
     1. Label: PRIDE project
     2. Name: Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model