PXD054693

PXD054693 is an original dataset announced via ProteomeXchange.

Title	Investigation of the rhythmic changes in the proteome of different subtypes of pancreatic ductal adenocarcinoma
Description	At present, there is no reliable biomarker for the diagnosis of pancreatic ductal adenocarcinoma (PDAC). Due to this, together with the asymptomatic nature of the cancer, PDAC is often diagnosed at an advanced stage with an abysmal 5-year survival rate. Hence, a reliable biomarker for the timely diagnosis of PDAC is essential. The altered levels of protein expression are one of the hallmarks of cancer. Understanding these changes in PDAC could yield insights into the development of the disease and hence could potentially identify new biomarkers. Hence, in this study, mass spectrometry-based label‐free quantitative proteomics was employed to investigate the differently expressed proteins in the pancreatic cancer cell lines (Capan-2 and PANC-1), benign pancreatic cells (hTERT-HPNE) and normal pancreatic duct epithelial cells (H6c7). Furthermore, to study the circadian variations in the secretome of the pancreatic cell lines, the rhythmic expression of proteins was investigated at 6-hour intervals over 24 hours. The findings of this study provide novel insights into the processes and pathways involved in PDAC, potentially leading to the identification of circadian-based subtype-specific biomarkers.
HostingRepository	PRIDE
AnnounceDate	2026-02-23
AnnouncementXML	Submission_2026-02-22_17:41:16.651.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jaime Jayapalan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-07 23:33:52	ID requested
⏵ 1	2026-02-22 17:41:17	announced

Vellan CJ, Peng Soon K, Abdul Aziz A, Jacqueline Jayapalan J, Circadian-rhythm-based dynamics of the secretome in molecular subtypes of pancreatic ductal adenocarcinoma. Expert Rev Proteomics, ():1-15(2026) [pubmed]

10.1080/14789450.2026.2634792;

submitter keyword: circadian rhythm,Label-free quantitative proteomics, mass spectrometry, PDAC, biomarker

Dr. Jaime Jacqueline Jayapalan
contact affiliation	Department of Molecular Medicine, Faculty of Medicine, Universiti Malaya, Malaysia
contact email	jaime_jacklyn@um.edu.my
lab head
Jaime Jayapalan
contact affiliation	University of Malaya
contact email	jaime_jacklyn@um.edu.my
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD054693

PRIDE project URI

• PRIDE
  1. PXD054693
     1. Label: PRIDE project
     2. Name: Investigation of the rhythmic changes in the proteome of different subtypes of pancreatic ductal adenocarcinoma