PXD054668

PXD054668 is an original dataset announced via ProteomeXchange.

Title	The glomerular circadian clock temporally regulates basement membrane dynamics and podocyte glucocorticoid response
Description	Kidneys were collected from wildtype mice over the course of two circadian cycles (every 4 hours for 48 hours), snap frozen, and later prepared for circadian proteomic analysis The purpose of this study was to investigate the correlation between rhythmic matrix gene expression and matrix protein abundance. To focus our analysis on the kidney matrix, we generated a matrix-enriched fraction. Samples were prepared for label-free mass spectrometry-based proteomics to define rhythmic changes in the protein composition of mouse kidneys.
HostingRepository	PRIDE
AnnounceDate	2026-02-04
AnnouncementXML	Submission_2026-02-04_09:09:25.327.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD054668
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Mychel Morais
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-07 03:15:55	ID requested
1	2026-02-02 07:37:20	announced
⏵ 2	2026-02-04 09:09:25	announced	2026-02-04: Updated project metadata.

10.1016/J.KINT.2024.10.016;

10.6019/PXD054668;

ProteomeXchange project tag: string

submitter keyword: kidney matrix, podocytes, glomerular basement membrane,Circadian rhythm, glucocorticoids

Rachel Lennon
contact affiliation	Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medical and Health Sciences. University of Manchester, UK.
contact email	rachel.lennon@manchester.ac.uk
lab head
Mychel Morais
contact affiliation	The University of Manchester
contact email	mychel.morais@manchester.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD054668

PRIDE project URI

• PRIDE
  1. PXD054668
     1. Label: PRIDE project
     2. Name: The glomerular circadian clock temporally regulates basement membrane dynamics and podocyte glucocorticoid response