PXD054629

PXD054629 is an original dataset announced via ProteomeXchange.

Title	Immunocompatible Elastomer with increased resistance to the foreign body response
Description	Polymeric elastomers are extensively employed to fabricate implants intended for prolonged implantation. However, implantation of the elastomers can induce strong immune rejection reaction known as foreign body response (FBR), resulting in the rejection of foreign implants and thereby diminishing their in vivo efficacy. Herein, we present a group of immunocompatible elastomers, termed easy-to-synthesize vinyl-based anti-FBR dense elastomers (EVADE), synthesized via a straightforward and scalable method. In contrast to the pronounced immune reaction triggered by the commonly used implantable elastomers, EVADE materials effectively suppress the inflammation and long-term capsule formation in subcutaneous models of rodents and non-human primates for at least one year and two months, respectively. Implantation of EVADE materials significantly reduces the expression of inflammation-related proteins S100A8/A9 in adjacent tissues compared to polydimethylsiloxane (PDMS). We also show that inhibition or knockout of S100A8/A9 leads to substantial attenuation of fibrosis in mice, suggesting a target for fibrosis inhibition. Continuous subcutaneous insulin infusion (CSII) catheters constructed from EVADE elastomers demonstrate significantly improved longevity and performance compared to commercial catheters. The EVADE materials reported here may enhance and extend function in various medical devices by resisting local immune responses to implanted biomaterials.
HostingRepository	PRIDE
AnnounceDate	2024-10-17
AnnouncementXML	Submission_2024-10-17_05:07:47.208.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xianchi Zhou
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	amidated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-06 02:09:24	ID requested
⏵ 1	2024-10-17 05:07:49	announced

10.1038/s41467-024-52023-z;

Zhou X, Lu Z, Cao W, Zhu Z, Chen Y, Ni Y, Liu Z, Jia F, Ye Y, Han H, Yao K, Liu W, Wang Y, Ji J, Zhang P, Immunocompatible elastomer with increased resistance to the foreign body response. Nat Commun, 15(1):7526(2024) [pubmed]

submitter keyword: foreign body response

Xianchi Zhou
contact affiliation	Zhejiang University, China
contact email	zhouxianchi@zju.edu.cn
lab head
Xianchi Zhou
contact affiliation	Zhejiang university
contact email	zhouxianchi@zju.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD054629

PRIDE project URI

• PRIDE
  1. PXD054629
     1. Label: PRIDE project
     2. Name: Immunocompatible Elastomer with increased resistance to the foreign body response