⮝ Full datasets listing
PXD054615
PXD054615 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Dapansutrile preserves pancreatic beta-cell function by regulating insulin vesicle membrane fusion and mitochondrial homeostasis |
| Description | DAPA improved pancreatic beta-cell function in diabetic mice by inhibiting NLRP3-Caspase-1 signaling, enhancing insulin vesicle fusion, and modulating mitochondrial homeostasis, indicating its potential as a novel treatment for diabetes. |
| HostingRepository | iProX |
| AnnounceDate | 2024-08-06 |
| AnnouncementXML | Submission_2026-03-04_23:14:07.920.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ying Wu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-08-05 20:34:01 | ID requested | |
| 1 | 2025-05-05 22:04:00 | announced | |
| ⏵ 2 | 2026-03-04 23:14:09 | announced | 2026-03-05: Add info. |
Publication List
| Wu Y, Fu H, Zhu M, Yao Y, Jin L, Lin X, Zhou J, Dapansutrile preserves pancreatic beta-cell function by regulating insulin vesicle membrane fusion and mitochondrial homeostasis. Diabetes Obes Metab, 28(4):3054-3069(2026) [pubmed] |
Keyword List
| submitter keyword: Dapansutrile, inflammasome inhibitor, insulin vesicles, mitochondria, NLRP3, pancreatic beta-cells |
Contact List
| Jiaqiang Zhou | |
|---|---|
| contact affiliation | Zhejiang University |
| contact email | zjq8866@zju.edu.cn |
| lab head | |
| Ying Wu | |
| contact affiliation | Zhejiang University |
| contact email | 924067279@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
