PXD054565

PXD054565 is an original dataset announced via ProteomeXchange.

Title	Fraxetin targets PTGR2 to produce anti-inflammatory effects on the host and reduce the toxicity of Pseudomonas aeruginosa
Description	Although the natural product fraxetin exhibits diverse biological functions, particularly in anti-inflammatory activities, its specific mechanism of action has remained unclear. Employing affinity-based protein profiling (AfBPP), prostaglandin reductase 2 (PTGR2), a key enzyme responsible for terminal inactivation of prostaglandins, is identified as the cellular target of fraxetin in host cells. Additionally, fraxetin is discovered to significantly reduce the production of pyoverdine in Pseudomonas aeruginosa, an essential virulence factor in its acute infections thereby protecting hosts from P. aeruginosa infection through anti-virulence mechanisms. Overall, our study elucidates the precise target of fraxetin and highlights the multifaceted nature of this bioactive natural product from both host and pathogen perspectives.
HostingRepository	iProX
AnnounceDate	2024-08-04
AnnouncementXML	Submission_2024-08-05_00:20:36.284.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Songyao Kang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090; scientific name: Pseudomonas aeruginosa PAO1; NCBI TaxID: 208964;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-05 00:15:37	ID requested
⏵ 1	2024-08-05 00:20:36	announced

Dataset with its publication pending

submitter keyword: Chemical Proteomics, Anti-inflammation, Pseudomonas aeruginosa, Virulence, Natural product

Weining Zhao
contact affiliation	Shenzhen Technology University
contact email	zhaoweining@sztu.edu.cn
lab head
Songyao Kang
contact affiliation	Shenzhen Technology University
contact email	1490555176@qq.com
dataset submitter

iProX dataset URI