PXD054553

PXD054553 is an original dataset announced via ProteomeXchange.

Title	Identification of transcription factors regulating CD22 transcription
Description	CD22 (also known as Siglec-2) belongs to the Siglec family of glycan-recognition proteins and negatively regulates B-cell receptor-mediated signaling. CD22 protein is known to be down-regulated in the B cells of patients with chronic lymphocytic leukemia (CLL). However, the mechanism regulating the transcription of CD22 is incompletely understood. In this study, we defined the minimal promoter region of the human CD22 gene, and systematically identified the proteins binding to the minimal promoter by DNA affinity-purification from the nuclear extracts of B cell lines and LC-MS/MS.
HostingRepository	PRIDE
AnnounceDate	2025-03-26
AnnouncementXML	Submission_2025-03-25_19:56:24.841.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bayarmaa Enkhbayar
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-03 07:23:24	ID requested
⏵ 1	2025-03-25 19:56:25	announced

10.1016/J.JBC.2025.108386;

submitter keyword: transcription factor, B lymphocytes, Burkitt lymphoma, minimal promoter, DNA pull down-proteomics,CD22, chronic lymphocytic leukemia

Takashi Angata
contact affiliation	Academia Sinica, Institute of Biological Chemistry
contact email	angata@gate.sinica.edu.tw
lab head
Bayarmaa Enkhbayar
contact affiliation	PhD student at the Institute of Biochemistry Department, National Taiwan University
contact email	misheelbayar@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD054553
     1. Label: PRIDE project
     2. Name: Identification of transcription factors regulating CD22 transcription