PXD054504

PXD054504 is an original dataset announced via ProteomeXchange.

Title	Aberrant troponin post-translational modifications with TNNT1 mutations
Description	TNNT1 mutations are associated with congenital myopathies. Here, we aimed to investigate whether troponin T post-translational modifications would be affected by the mutations. For that, we used muscle biopsy specimens from patients with TNNT1 mutations and controls. We then defined the nature and location of troponin T post-translational modifications using LC/MS.
HostingRepository	PRIDE
AnnounceDate	2025-01-08
AnnouncementXML	Submission_2025-01-08_02:58:29.233.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michael Wierer
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-01 09:02:28	ID requested
⏵ 1	2025-01-08 02:58:29	announced

Dataset with its publication pending

submitter keyword: troponin, genetic disorder,Skeletal muscle

Julien Ochala
contact affiliation	University of Copenhagen Department of Biomedical Sciences Blegdamsvej 3B København N, DK-2200
contact email	julien.ochala@sund.ku.dk
lab head
Michael Wierer
contact affiliation	Proteomics Research Infrastructure, University of Copenhagen
contact email	michael.wierer@sund.ku.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD054504

PRIDE project URI

• PRIDE
  1. PXD054504
     1. Label: PRIDE project
     2. Name: Aberrant troponin post-translational modifications with TNNT1 mutations