PXD054502

PXD054502 is an original dataset announced via ProteomeXchange.

Title	Alterations in the nascent proteome during translation attenuation in response to mitochondrial stress induced by carbonyl cyanide m-chlorophenyl hydrazine (CCCP) and in response to EEF1A1 knockdown
Description	This submission is a part of a proteomic resource consisting of four independent datasets and their meta-analysis which describe: the detailed landscape of changes in the nascent proteome at high temporal resolution with 30 min intervals upon rapid and reversible global translation attenuation in response to transient mitochondrial membrane depolarization and during the subsequent recovery of physiological translation upon the relief of this stress (PXD043942), comparison of nascent proteome alterations in response to two types of challenge to protein homeostasis – proteasome inhibition and mitochondrial inner membrane depolarization (this submission, datasets expII and expIV) and finally nascent proteome alterations happening after silencing of elongation factor EEF1A1 in untreated and stress conditions (this submission, dataset expIII).
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_07:00:25.495.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Remigiusz Serwa
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-01 08:04:40	ID requested
1	2024-10-02 04:33:26	announced
⏵ 2	2024-10-22 07:00:25	announced	2024-10-22: Updated project metadata.

10.1016/J.CELREP.2024.114803;

submitter keyword: mitochondria, EEF1A1 elongation factor,mitochondrial stress, nascent proteome, CCCP

Agnieszka Chacinska
contact affiliation	IMol Polish Academy of Sciences, Warsaw, Poland
contact email	a.chacinska@imol.institute
lab head
Remigiusz Serwa
contact affiliation	The International Institute of Molecular Mechanisms and Machines, Polish Academy of Sciences
contact email	r.serwa@imol.edu.pl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD054502

PRIDE project URI

• PRIDE
  1. PXD054502
     1. Label: PRIDE project
     2. Name: Alterations in the nascent proteome during translation attenuation in response to mitochondrial stress induced by carbonyl cyanide m-chlorophenyl hydrazine (CCCP) and in response to EEF1A1 knockdown