PXD054499

PXD054499 is an original dataset announced via ProteomeXchange.

Title	Identification of cardiac myosin heavy chain post-translational modifications in hibernating grizzly bears
Description	Mammal hibernation is a physiological process with unclear molecular mechanisms. Here, we aimed to investigate whether cardiac myosin heavy chain post-translational modifications would be affected by hibernation. For that, we used cardiac left ventricle specimens from active and hibernating adult grizzly bears. We then defined the nature and location of cardiac myosin heavy chain post-translational modifications using LC/MS.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-06_23:33:18.069.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michael Wierer
SpeciesList	scientific name: Ursus arctos (Brown bear) (Grizzly bear); NCBI TaxID: 9644;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Ascend

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-01 07:35:42	ID requested
⏵ 1	2025-05-06 23:33:18	announced

10.1016/j.molmet.2024.102084;

Van der Pijl RJ, Ma W, Lewis CTA, Haar L, Buhl A, Farman GP, Rhodehamel M, Jani VP, Nelson OL, Zhang C, Granzier H, Ochala J, Increased cardiac myosin super-relaxation as an energy saving mechanism in hibernating grizzly bears. Mol Metab, 92():102084(2025) [pubmed]

submitter keyword: bear, PTM,myosin

Julien Ochala
contact affiliation	University of Copenhagen Department of Biomedical Sciences Blegdamsvej 3B København N, DK-2200
contact email	julien.ochala@sund.ku.dk
lab head
Michael Wierer
contact affiliation	Proteomics Research Infrastructure, University of Copenhagen
contact email	michael.wierer@sund.ku.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD054499

PRIDE project URI

• PRIDE
  1. PXD054499
     1. Label: PRIDE project
     2. Name: Identification of cardiac myosin heavy chain post-translational modifications in hibernating grizzly bears