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PXD054498

PXD054498 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMultiple classes of antigen contribute to the antigenic landscape of mesothelioma
DescriptionMesothelioma is an incurable, asbestos-exposure related cancer that typically affects the lining or pleura of the lungs. Symptoms typically develop many decades after initial exposure to asbestos, leaving an enduring legacy of disease. Vaccine-induced augmentation of immune responses unleashed during checkpoint blockade may provide further clinical benefit in mesothelioma. In this study we explore the HLA class I antigenic landscape (or immunopeptidome) of mesothelioma in patient derived cell line and clinical material (pleural effusion samples).
HostingRepositoryPRIDE
AnnounceDate2025-05-07
AnnouncementXMLSubmission_2025-05-06_23:05:21.852.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD054498
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterKirti Pandey
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue; monohydroxylated residue; L-cysteine amide; deamidated residue
InstrumentBruker Daltonics timsTOF series
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-08-01 07:30:53ID requested
12025-05-06 23:05:22announced
Publication List
10.1016/j.mcpro.2025.100925;
10.6019/PXD054498;
Pandey K, Faridi P, Ayala R, Lee YCG, Rouse E, Krishna SSG, Dick I, Redwood A, Robinson B, Creaney J, Purcell AW, Multiple Classes of Antigen Contribute to the Antigenic Landscape of Mesothelioma. Mol Cell Proteomics, 24(3):100925(2025) [pubmed]
Keyword List
submitter keyword: mass spectrometry,HLA class I, Mesothelioma, asbestos related cancer, Immunopeptidomics, lung cancer
Contact List
Anthony Wayne
contact affiliationDepartment of Biochemistry and Molecular Biology and Infection and Immunity Program, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia
contact emailanthony.purcell@monash.edu
lab head
Kirti Pandey
contact affiliationMonash University
contact emailkirti.pandey1@monash.edu
dataset submitter
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Dataset FTP location
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Repository Record List
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