PXD054498

PXD054498 is an original dataset announced via ProteomeXchange.

Title	Multiple classes of antigen contribute to the antigenic landscape of mesothelioma
Description	Mesothelioma is an incurable, asbestos-exposure related cancer that typically affects the lining or pleura of the lungs. Symptoms typically develop many decades after initial exposure to asbestos, leaving an enduring legacy of disease. Vaccine-induced augmentation of immune responses unleashed during checkpoint blockade may provide further clinical benefit in mesothelioma. In this study we explore the HLA class I antigenic landscape (or immunopeptidome) of mesothelioma in patient derived cell line and clinical material (pleural effusion samples).
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-06_23:05:21.852.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD054498
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Kirti Pandey
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; L-cysteine amide; deamidated residue
Instrument	Bruker Daltonics timsTOF series

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-01 07:30:53	ID requested
⏵ 1	2025-05-06 23:05:22	announced

10.1016/j.mcpro.2025.100925;

10.6019/PXD054498;

Pandey K, Faridi P, Ayala R, Lee YCG, Rouse E, Krishna SSG, Dick I, Redwood A, Robinson B, Creaney J, Purcell AW, Multiple Classes of Antigen Contribute to the Antigenic Landscape of Mesothelioma. Mol Cell Proteomics, 24(3):100925(2025) [pubmed]

submitter keyword: mass spectrometry,HLA class I, Mesothelioma, asbestos related cancer, Immunopeptidomics, lung cancer

Anthony Wayne
contact affiliation	Department of Biochemistry and Molecular Biology and Infection and Immunity Program, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia
contact email	anthony.purcell@monash.edu
lab head
Kirti Pandey
contact affiliation	Monash University
contact email	kirti.pandey1@monash.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD054498

PRIDE project URI

• PRIDE
  1. PXD054498
     1. Label: PRIDE project
     2. Name: Multiple classes of antigen contribute to the antigenic landscape of mesothelioma