⮝ Full datasets listing
PXD054458
PXD054458 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | First Evidence of an Involvement of the Calcitonin Gene Related Peptide in Restless Legs Syndrome |
| Description | Abstract Background Restless legs syndrome (RLS) is a common sensory-motor disorder characterized by an urge to move the legs, often with unpleasant sensations, particularly during rest. Current treatments include iron supplementation, dopamine agonists, and opioids, but new therapeutic approaches are needed. The dysfunction of the A11 nucleus, which modulates dopaminergic transmission to the spinal cord, is thought to play a role in RLS pathophysiology. Calcitonin gene-related peptide (CGRP), which is involved in pain modulation, may interact with A11 pathways, suggesting a role in RLS. Objectives This study aimed to assess the involvement of CGRP in RLS by determining if CGRP-related proteins are overexpressed in RLS patients. Methods A cross-sectional study was conducted with 17 drug-free RLS patients (mean age 55.8?years) and 17 age- and gender-matched controls. Serum samples were analyzed using liquid chromatography-parallel reaction monitoring-tandem mass spectrometry (LC-PRM-MS/MS) to identify and quantify CGRP-related proteins. Principal component analysis (PCA) was used to differentiate between groups. Results PCA showed clear differentiation between RLS and control groups. Among 13 identified CGRP-related proteins, 10 were dysregulated in RLS patients: 8 were upregulated, and 2 were downregulated, among them notable proteins such as S100A12, ADM, SRSF6, and ADM2. Conclusions This study indicates the significant involvement of CGRP and related proteins in RLS. This suggests these proteins may play roles in various aspects of the disorder. Further research is required to validate these findings and explore their clinical implications, including development of new treatment options that specifically address CGRP pathways. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-09-07 |
| AnnouncementXML | Submission_2026-09-07_21:32:54.467.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Mojibola Fowowe |
| SpeciesList | scientific name: homo sapiens; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-07-31 12:09:54 | ID requested | |
| ⏵ 1 | 2026-09-07 21:32:55 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: RLS, Restless leg syndrome, CGRP, Proteomics |
Contact List
| Yehia Mechref | |
|---|---|
| contact affiliation | Texas Tech University |
| contact email | yehia.mechref@ttu.edu |
| lab head | |
| Mojibola Fowowe | |
| contact affiliation | Texas Tech University |
| contact email | mfowowe@ttu.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v08/MSV000095499/ |
