PXD054457
PXD054457 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Exploring Protein Post-Translational Modifications of Breast Cancer Cells Using a Novel Combinatorial Search Algorithm |
| Description | Post-translational modification of proteins plays an important role in cancer cell biology. Protein encoded by oncogenes may be activated by phosphorylation, products of tumour suppressors might be inactivated by phosphorylation or ubiquitination, which marks them for degradation; Chromatin binding proteins are often methylated and/or acetylated. These are just a few of the many hundreds of post-translational modifications discovered by years of painstaking experimentation and chemical analysis of purified proteins. In recent years, mass spectrometry-based proteomics emerged as the principal technique for identifying such modifications in samples from cultured cells and tumour tissue. Here we used a recently developed combinatorial search algorithm implemented in the MGVB toolset to identify novel modifications in samples from breast cancer cell lines. Our results provide a rich resource of coupled protein abundance and post-translational modification data seen in the context of an important biological function - the response of cells to interferon gamma treatment - which can serve as a starting point for future investigations to validate promising modifications and explore the utility of the underlying molecular mechanisms as potential diagnostic or therapeutic targets. |
| HostingRepository | MassIVE |
| AnnounceDate | 2024-09-12 |
| AnnouncementXML | Submission_2024-09-12_09:21:05.484.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Metodi V. Metodiev |
| SpeciesList | scientific name: Homo sapiens; |
| ModificationList | unknown modification; GG |
| Instrument | instrument model |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-07-31 10:43:46 | ID requested | |
| ⏵ 1 | 2024-09-12 09:21:05 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: breast cancer, interferon gamma, PTM, methylation |
Contact List
| Metoodi V. Metodiev | |
|---|---|
| contact affiliation | University of Essex |
| contact email | mmetod@essex.ac.uk |
| lab head | |
| Metodi V. Metodiev | |
| contact affiliation | University of Essex |
| contact email | mmetod@essex.ac.uk |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v08/MSV000095497/ |
to receive all new ProteomeXchange dataset release announcements!
