PXD054353

PXD054353 is an original dataset announced via ProteomeXchange.

Title	Phospho-proteome of vascular smooth muscle cells derived from abdominal aortic aneurysm patients
Description	For this experiment, primary smooth muscle cells (SMC) were isolated from abdominal aortic aneurysm (AAA) patients. Control SMC (c-SMC) were isolated from non-dilated human aortas. SMC contraction from AAA-patients and controls was measured. SMC contraction from AAA patients shows a broad range, with higher, lower and normal contracting SMC, compared to c-smc in which a stable normal contraction is seen. We aim to understand the underlying mechanism explaining these differences in SMC contraction.
HostingRepository	PRIDE
AnnounceDate	2025-07-14
AnnouncementXML	Submission_2025-07-14_05:38:26.210.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thang Pham
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-29 13:52:46	ID requested
⏵ 1	2025-07-14 05:38:27	announced

10.1161/atvbaha.124.321087;

Rombouts KB, van Merrienboer TAR, Henneman AA, Knol JC, Pham TV, Piersma SR, Jimenez CR, Bogunovic N, van der Velden J, Yeung KK, Insight in the (Phospho)proteome of Vascular Smooth Muscle Cells Derived From Patients With Abdominal Aortic Aneurysm Reveals Novel Disease Mechanisms. Arterioscler Thromb Vasc Biol, 44(10):2226-2243(2024) [pubmed]

submitter keyword: Abdominal Aortic Aneurysm

Contractile function

Proteomics

Vascular biology

Vascular smooth muscle cells

Connie Jimenez
contact affiliation	Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands
contact email	c.jimenez@amsterdamumc.nl
lab head
Thang Pham
contact affiliation	Amsterdam UMC
contact email	t.pham@amsterdamumc.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD054353

PRIDE project URI

• PRIDE
  1. PXD054353
     1. Label: PRIDE project
     2. Name: Phospho-proteome of vascular smooth muscle cells derived from abdominal aortic aneurysm patients