PXD054319

PXD054319 is an original dataset announced via ProteomeXchange.

Title	Pan-cancer and multi-omics analyses reveal the diagnostic and prognostic value of BAZ2B
Description	The BAZ2B gene belongs to the bromodomain gene family. The proteins encoded by members of this gene family are important components of chromatin remodelling complexes and have a potential role in transcriptional activation. However, the biological significance of BAZ2B in pan-cancer is unknown. In this study, we comprehensively analysed the functional characteristics of BAZ2B in human cancers and its role in immune response using The Cancer Genome Atlas (TCGA), Gene Expression Album (GEO), Genotype-Tissue Expression (GTEx) databases, and tools such as TIMER 2.0 and cBioPortal, and found that BAZ2B is down-regulated in certain cancers, and its overexpression is associated with patients’ poor prognosis, such as bladder, breast and endometrial cancers. In addition, we demonstrated for the first time that BAZ2B was under-expressed in breast cancer cells and promoted proliferation, migration and apoptosis of breast cancer cells.
HostingRepository	iProX
AnnounceDate	2024-07-26
AnnouncementXML	Submission_2024-07-28_23:11:30.076.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jimin Guo
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-28 23:10:37	ID requested
⏵ 1	2024-07-28 23:11:30	announced

Dataset with its publication pending

submitter keyword: BAZ2B, pan-cancer, prognosis, immune infiltration, enrichment analysis, BRCA

Yan Liu
contact affiliation	North China University of Science and Technology
contact email	liuysm@ncst.edu.cn
lab head
Jimin Guo
contact affiliation	North China University of Science and Technology
contact email	g1595594565@163.com
dataset submitter

iProX dataset URI