PXD054301

PXD054301 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Inhibition of mTOR attenuates the initiation and progression of BRCA1-associated mammary tumors
Description	We conducted global proteome and phosphoproteome profiling of vehicle- and everolimus-treated tumors from 17 mice that were allografted with spontaneously developed mammary tumors from Brca1co/coMMTV-Cre mice using LC-MS/MS. The Proteome Discoverer analysis identified 9,625 proteins having two unique sibling peptides and more and 35,142 phosphopeptides with a peptide- and protein-level FDR of 1% using SEQUEST-HT algorithm. We defined everolimus-sensitive and resistant tumors based on proteome and phosphoproteome data, and identified protein and phosphopeptide signatures defining each cluster. Pathway enrichment analysis of these signatures further revealed that leukotriene-neutrophil activation pathways were upregulated in everolimus-resistant tumors.
HostingRepository	PRIDE
AnnounceDate	2025-01-24
AnnouncementXML	Submission_2025-01-24_06:21:56.021.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD054301
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Geun Hee Han
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-28 00:32:47	ID requested
⏵ 1	2025-01-24 06:21:56	announced

Publication List

Baek HJ, Han GH, Cho EJ, Xu J, Ki MK, Park EJ, Kim TH, Shin DH, Cheong H, Deng CX, Lim SC, Hwang CI, Hwang D, Kim SS, Inhibition of mTOR attenuates the initiation and progression of BRCA1-associated mammary tumors. Cancer Commun (Lond), 45(4):486-490(2025) [pubmed]
10.1002/cac2.12663;
10.6019/PXD054301;

Baek HJ, Han GH, Cho EJ, Xu J, Ki MK, Park EJ, Kim TH, Shin DH, Cheong H, Deng CX, Lim SC, Hwang CI, Hwang D, Kim SS, Inhibition of mTOR attenuates the initiation and progression of BRCA1-associated mammary tumors. Cancer Commun (Lond), 45(4):486-490(2025) [pubmed]

10.1002/cac2.12663;

10.6019/PXD054301;

Keyword List

submitter keyword: everolimus,BRCA1, LC-MS/MS

submitter keyword: everolimus,BRCA1, LC-MS/MS

Contact List

Daehee Hwang
contact affiliation	School of Biological Sciences, Seoul National University, Seou, 08826, Korea
contact email	daehee@snu.ac.kr
lab head
Geun Hee Han
contact affiliation	Seoul National University
contact email	kh7han@snu.ac.kr
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD054301
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD054301

PRIDE project URI

Repository Record List

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