PXD054291

PXD054291 is an original dataset announced via ProteomeXchange.

Title	Rac1 inhibition prevents cytoskeleton dysfunction and axonal degeneration in Transthyretin Amyloid Polyneuropathy
Description	Transthyretin Amyloid Polyneuropathy (ATTR-PN) is characterized by the deposition of amyloidogenic TTR particularly in dorsal root ganglia (DRG) and peripheral nerve axons leading to a sensory axonopathy. Here, we investigated the role of cytoskeleton alterations in peripheral axons from an ATTR-PN mouse model. We employed the knock-in hTTRA97S mouse model for ATTR-PN to examine cellular and molecular changes in peripheral axons. Our approach included proteomic analysis of the sural nerve, live imaging techniques, and pharmacological intervention targeting Rac1. Additionally, we used DNA samples gathered from individuals diagnosed with ATTR-PN, including early-onset and late-onset cases, to uncover genetic variants of cytoskeleton regulators related to distinct disease onsets.
HostingRepository	PRIDE
AnnounceDate	2025-10-10
AnnouncementXML	Submission_2025-10-10_08:52:58.386.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vítor Dias
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-26 14:23:04	ID requested
⏵ 1	2025-10-10 08:52:59	announced

10.1016/J.CELREP.2025.116411;

submitter keyword: transthyretin

axonopathy

Transthyretin Amyloid Polyneuropathy

cytoskeleton

microtubule dynamics

actin

axonal transport

peripheral nervous system

Rac1

Márcia A Liz
contact affiliation	Nerve Regeneration Group, Neurodegeneration Team, IBMC/i3S
contact email	mliz@i3s.up.pt
lab head
Vítor Dias
contact affiliation	Nerve Regeneration Group, Neurodeneration Team, i3S - Institute for Research and Innovation in Health
contact email	vitor.dias@i3s.up.pt
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD054291

PRIDE project URI

• PRIDE
  1. PXD054291
     1. Label: PRIDE project
     2. Name: Rac1 inhibition prevents cytoskeleton dysfunction and axonal degeneration in Transthyretin Amyloid Polyneuropathy