PXD054270

PXD054270 is an original dataset announced via ProteomeXchange.

Title	Peroxisomal proteome of prostate (cancer) cells
Description	Prostate cancer (PCa) is the second most common cancer and fifth leading cause of cance death among men worldwide. Intriguingly, primary prostate tumors do not undergo a metabolic switch from oxidative phosphorylation to aerobic glycolysis to meet increased energetic and biosynthetic demand for cell growth and division. In contrast, PCa cells preferentially use fatty acids for metabolic fuel, and malignant transformation of prostate tissue is accompanied by a sustained increase in the activity of both lipogenic and oxidative enzymes. As peroxisomes (PO) play a key role in cellular lipid and redox metabolism, it may not come as a surprise that these organelles are increasingly recognized as being involved in the pathogenesis of PCa. However, many uncertainties and inadequacies in our understanding of how PO function in PCa progression remain. This project is intended to gain a more coherent picture of how alterations in PO metabolism contribute to PCa development, progression, and therapy response. Specifically, by employing cutting-edge technologies, we systematically inventory which peroxisomal parameters are affected in commonly used cell models of PCa.
HostingRepository	PRIDE
AnnounceDate	2024-11-01
AnnouncementXML	Submission_2024-11-01_11:11:49.881.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mohamed Hussein
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	ZenoTOF 7600

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-26 04:55:03	ID requested
⏵ 1	2024-11-01 11:11:50	announced

10.3390/ANTIOX13111340;

submitter keyword: LC-MSMS,Peroxisomes, RWPE-1, 22Rv1, LNCaP, PC3

Marc Fransen
contact affiliation	Laboratory of Peroxisome Biology and Intracellular Communication, Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
contact email	marc.fransen@kuleuven.be
lab head
Mohamed Hussein
contact affiliation	Laboratory of Peroxisome Biology and Intracellular Communication, Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
contact email	mohamed.hussein@kuleuven.be
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/11/PXD054270

PRIDE project URI

• PRIDE
  1. PXD054270
     1. Label: PRIDE project
     2. Name: Peroxisomal proteome of prostate (cancer) cells