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PXD054266

PXD054266 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic Characterisation of Heart Failure Reveals Unique Molecular Phenotype for Hypertrophic Cardiomyopathy
DescriptionHypertrophic cardiomyopathy (HCM) is a disease, which is difficult to diagnose at an early stage and for which there is a pressing need for more effective treatment options. The purpose of this study was to compare the molecular profile of HCM to that of ISCM and DCM for identification of protein and pathway targets that could support development of better diagnostic and treatment options for HCM. A high throughput mass spectrometry workflow was applied to achieve deep quantitative coverage of left ventricular tissue from HCM, DCM, ISCM and non-heart failure control patients. HCM had a diverse proteomic profile compared to that of DCM and ISCM. Dif-ferentially expressed proteins unique to HCM were identified based on an observed fold change of ≥ 1.5 or ≤-1.5 and q-value ≤ 0.005. Candidate proteins of interest were found to be significantly associated with clinical features of HCM. The significant association between these proteins and HCM was validated in an independent dataset. This represents one of the largest and deepest proteomic datasets for myocardial tissue reported to date. The dataset highlights the diverse proteomic profile of HCM, relative to other cardiomyopathies, and reveals disease-relevant pathways and promising biomarker candidates that are uniquely associated with HCM.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:53:10.235.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBen Collins
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-07-26 02:16:20ID requested
12024-08-08 05:22:54announced
22024-10-22 06:53:10announced2024-10-22: Updated project metadata.
Publication List
10.3390/BIOMEDICINES12081712;
Keyword List
submitter keyword: ypertrophic cardiomyopathy, DIA, diaPASEF, biomarkers
Contact List
Ben Collins
contact affiliationQueen's University Belfast
contact emailben.collins@qub.ac.uik
lab head
Ben Collins
contact affiliationQueen's University Belfast
contact emailben.collins@qub.ac.uk
dataset submitter
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Dataset FTP location
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PRIDE project URI
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