PXD054221 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Physical interaction with Ephrin B1 promotes CXCR4 intracellular localization and oncogenic potential |
| Description | Chemokine receptor 4 (CXCR4) is a member of the chemokine receptor family that is overexpressed in various cancer types and has been involved in cancer progression and metastasis. In light of recent findings suggesting that intracellular CXCR4 rather than CXCL12-CXCR4-operated signaling promotes cancer cell survival and accumulating evidence indicating that the trafficking and targeting of G protein-coupled receptors (GPCRs) to specific cellular compartments depends on their association with protein partners, we characterized the CXCR4 interactome in HEK-293 cells using an affinity purification-mass spectrometry (AP-MS) strategy. These studies identified Ephrin B1 as a major protein partner of CXCR4 that plays a key role in its intracellular localization and signal transduction. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-26 |
| AnnouncementXML | Submission_2026-06-26_08:28:31.480.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Functional Proteomics Platform FPP |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | LTQ Orbitrap Elite |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-07-25 02:35:09 | ID requested | |
| ⏵ 1 | 2026-06-26 08:28:31 | announced | |
Publication List
Keyword List
| submitter keyword: G protein-coupled receptor, AP-MS, CXCR4, chemokine, signalling, trafficking, Ephrin, interactome |
Contact List
| Philippe Marin |
|---|
| contact affiliation | Institute of Functional Genomics, Univ. Montpellier, CNRS, INSERM, Montpellier, France |
| contact email | philippe.marin@igf.cnrs.fr |
| lab head | |
| Functional Proteomics Platform FPP |
|---|
| contact affiliation | FPP CNRS |
| contact email | contact@fpp.cnrs.fr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD054221 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD054221
- Label: PRIDE project
- Name: Physical interaction with Ephrin B1 promotes CXCR4 intracellular localization and oncogenic potential
