PXD054190

PXD054190 is an original dataset announced via ProteomeXchange.

Title	Label-based comparative proteomics to understand progression of precancerous lesions to oral squamous cell carcinoma
Description	Oral squamous cell carcinomas typically arise from precancerous lesions such as leukoplakia and erythroplakia. These lesions exhibit a range of histological changes from hyperplasia to dysplasia and carcinoma in situ, during their transformation to malignancy. The molecular mechanisms driving this multistage transition remain incompletely understood. To bridge this knowledge gap, our current study utilizes label based comparative proteomics to compare protein expression profiles across different histopathological grades of leukoplakia, erythroplakia, and OSCC samples, aiming to elucidate the molecular changes underlying lesion evolution.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-06_22:17:28.078.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	GURURAO HARIPRASAD
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-24 11:23:41	ID requested
⏵ 1	2025-05-06 22:17:29	announced

10.1016/j.bbrep.2024.101842;

Sharma V, Singh SB, Bandyopadhyay S, Sikka K, Kakkar A, Hariprasad G, Label-based comparative proteomics of oral mucosal tissue to understand progression of precancerous lesions to oral squamous cell carcinoma. Biochem Biophys Rep, 40():101842(2024) [pubmed]

submitter keyword: erythroplakia,oral squamous cell carcinoma, label-based proteomics, leukoplakia

Hariprasad Gururao
contact affiliation	Professor, Deptt of Biophysics, All India Institute of Medical Sciences, New Delhi, India
contact email	dr.hariprasadg@gmail.com
lab head
GURURAO HARIPRASAD
contact affiliation	Department of Biophysics All India Institute of Medical Sciences New Delhi India
contact email	dr.hariprasadg@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD054190

PRIDE project URI

• PRIDE
  1. PXD054190
     1. Label: PRIDE project
     2. Name: Label-based comparative proteomics to understand progression of precancerous lesions to oral squamous cell carcinoma