PXD054170

PXD054170 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis identifies dysregulated proteins in albuminuria: a South African pilot study
Description	Chronic kidney disease remains an unmet clinical challenge. It is only detected at advanced stages by current markers. Therefore, early detection of chronic kidney disease is vital. In this study, we profiled the urinary proteome in patients with albuminuria with well-preserved eGFR. We identi-fied 80 proteins that were differentially abundant between cases (albuminuria) and controls (normoalbuminuria). Among these, 12 proteins (SERPINA1, ALB, SERPINC1, AFM, PIGR, A1BG, COL6A1, MYG, LV39, MUC1, ICOSLG, and UMOD) had the highest discriminating abilities (area under curve > 0.8) between cases and controls. When differentially abundant proteins were com-bined into an 80-protein model, the model was able to predict cases from controls with predictive accuracy of 91.3%. The top five enriched biological pathways associated with differentially abundant proteins included insulin growth factor functions, innate immunity, platelet degranula-tion, and extracellular matrix organization.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-06_23:25:59.199.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ireshyn Govender
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-24 01:09:58	ID requested
⏵ 1	2025-05-06 23:26:00	announced

Publication List

10.3390/ijms26041740;
Khoza S, George JA, Naicker P, Stoychev SH, Mokoena RJ, Govender IS, Fabian J, Distinct Urinary Proteome Changes Across Estimated Glomerular Filtration Rate Stages in a Cohort of Black South Africans. Int J Mol Sci, 26(4):(2025) [pubmed]

10.3390/ijms26041740;

Khoza S, George JA, Naicker P, Stoychev SH, Mokoena RJ, Govender IS, Fabian J, Distinct Urinary Proteome Changes Across Estimated Glomerular Filtration Rate Stages in a Cohort of Black South Africans. Int J Mol Sci, 26(4):(2025) [pubmed]

Keyword List

submitter keyword: urinary proteomics
albuminuria
chronic kidney disease
biomarker,ne

submitter keyword: urinary proteomics

albuminuria

chronic kidney disease

biomarker,ne

Contact List

Previn Naicker
contact affiliation	Council for Scientific and Industrial Research
contact email	pnaicker1@csir.co.za
lab head
Ireshyn Govender
contact affiliation	Council for Scientific and Industrial Research
contact email	igovender@csir.co.za
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD054170
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD054170

PRIDE project URI

Repository Record List

[ + ]