PXD054158 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | ThermoTargetMiner: Proteome Integral Solubility Alteration (PISA) target database for prospective lung cancer drug candidates |
| Description | Knowledge of the targets of therapeutic compounds helps understanding the compound action mechanism as well as the side-effects. The multiple complementary techniques needed for comprehensive target characterization must combine data reliability with sufficient analysis throughput. Here, we test the Proteome Integral Solubility Alteration (PISA) assay by target identification of 67 approved anticancer drugs and candidates against pulmonary carcinoma. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-10 |
| AnnouncementXML | Submission_2026-06-09_21:00:16.940.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hezheng Lyu |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos; Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-07-23 17:45:56 | ID requested | |
| ⏵ 1 | 2026-06-09 21:00:17 | announced | |
Publication List
Keyword List
| submitter keyword: Human, proteomics, LC-MS, lung cancer |
Contact List
| Roman Zubarev |
|---|
| contact affiliation | Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 65 Stockholm, Sweden |
| contact email | roman.zubarev@ki.se |
| lab head | |
| Hezheng Lyu |
|---|
| contact affiliation | Karolinska Institutet |
| contact email | hezheng.lyu@ki.se |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD054158 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD054158
- Label: PRIDE project
- Name: ThermoTargetMiner: Proteome Integral Solubility Alteration (PISA) target database for prospective lung cancer drug candidates
