PXD054157

PXD054157 is an original dataset announced via ProteomeXchange.

Title	LZTR1 is a Melanoma Oncogene that Promotes Cell Growth and Inhibits Apoptosis Under Stress
Description	LZTR1 is known to act as a tumor suppressor in glioma, acting as an adaptor protein for Cullin 3 (CUL3) ubiquitin ligase. However, we demonstrated that LZTR1 is amplified in acral melanomas, and is required for melanoma cell proliferation and anchorage-independent growth. To understand the molecular mechanisms by which LZTR1 amplification promotes melanomas, we carried out proximity biotinylation by TurboID and co-immunoprecipitation assays. We identified LZTR1 proximal proteins associated not only with ubiquitination and autophagy, but also with de-ubiquitination, focal adhesion, stress response, and actin cytoskeleton. LZTR1 is not “just” an adaptor protein for Cullin 3 (CUL3) ubiquitin ligase complex but is a hub for additional molecular functions such as de-ubiquitination and actin organization that confer context-dependent tumor promoting activity. Downregulation of LZTR1 is therefore a novel cell death mechanism that can be targeted for melanoma therapy.
HostingRepository	PRIDE
AnnounceDate	2025-10-13
AnnouncementXML	Submission_2025-10-12_16:34:16.177.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD054157
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Haomiao Su
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-23 16:17:29	ID requested
⏵ 1	2025-10-12 16:34:17	announced

10.6019/PXD054157;

10.1038/s41388-025-03538-2;

Bacchiocchi A, Mak M, Khan ZM, Gong X, Sznol M, Na Z, Su H, Chan LH, Yan Q, Zhao D, Mortlock RD, Knight J, Slavoff SA, Halaban R, LZTR1 is a melanoma oncogene that promotes invasion and suppresses apoptosis. Oncogene, 44(41):3974-3984(2025) [pubmed]

submitter keyword: autophagy, stress response,LZTR1, acral melanoma

Sarah A Slavoff
contact affiliation	Chemisrty department Yale University
contact email	slavoff.sarah@yale.edu
lab head
Haomiao Su
contact affiliation	Yale University
contact email	suhaomiao@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD054157

PRIDE project URI

• PRIDE
  1. PXD054157
     1. Label: PRIDE project
     2. Name: LZTR1 is a Melanoma Oncogene that Promotes Cell Growth and Inhibits Apoptosis Under Stress