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PXD054069

PXD054069 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLC/MS Analysis of Phosphorylated Protein Changes in Mouse Brain Tissue After LPS Treatment and Angong Niuhuang Wan Administration
DescriptionIntroduction: Angong Niuhuang Wan (AGNHW), developed in the Qing dynasty (18th century) for treating consciousness disturbances caused by severe infections, has already been used to treat brain edema caused by ischemia-reperfusion. However, it remains unclear whether AGNHW can ameliorate vascular-origin brain edema caused by lipopolysaccharides (LPS).This study explores the ameliorative effects of AGNHW on cerebrovascular edema in mice caused by LPS, as well as its potential mechanisms.Mice were divided into four groups: Control, LPS 26 h, LPS 48 h, and LPS + AGNHW_M. Enriched phosphorylated peptides were extracted from mouse brain tissues at the corresponding time points and subjected to phosphoproteomic analysis.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:51:24.141.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBoTong Liu
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListphosphorylated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-07-19 10:21:18ID requested
12024-07-25 09:50:56announced
22024-10-22 06:51:24announced2024-10-22: Updated project metadata.
Publication List
10.3389/FPHAR.2024.1421635;
Keyword List
submitter keyword: LC/MS,AGNHW,Phosphoproteome
Contact List
Jing-Yan Han
contact affiliationDepartment of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University
contact emailhanjingyan@bjmu.edu.cn
lab head
BoTong Liu
contact affiliationPeking university
contact emailliubotong@163.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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