PXD054069

PXD054069 is an original dataset announced via ProteomeXchange.

Title	LC/MS Analysis of Phosphorylated Protein Changes in Mouse Brain Tissue After LPS Treatment and Angong Niuhuang Wan Administration
Description	Introduction: Angong Niuhuang Wan (AGNHW), developed in the Qing dynasty (18th century) for treating consciousness disturbances caused by severe infections, has already been used to treat brain edema caused by ischemia-reperfusion. However, it remains unclear whether AGNHW can ameliorate vascular-origin brain edema caused by lipopolysaccharides (LPS).This study explores the ameliorative effects of AGNHW on cerebrovascular edema in mice caused by LPS, as well as its potential mechanisms.Mice were divided into four groups: Control, LPS 26 h, LPS 48 h, and LPS + AGNHW_M. Enriched phosphorylated peptides were extracted from mouse brain tissues at the corresponding time points and subjected to phosphoproteomic analysis.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:51:24.141.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	BoTong Liu
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-19 10:21:18	ID requested
1	2024-07-25 09:50:56	announced
⏵ 2	2024-10-22 06:51:24	announced	2024-10-22: Updated project metadata.

10.3389/FPHAR.2024.1421635;

submitter keyword: LC/MS,AGNHW,Phosphoproteome

Jing-Yan Han
contact affiliation	Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University
contact email	hanjingyan@bjmu.edu.cn
lab head
BoTong Liu
contact affiliation	Peking university
contact email	liubotong@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD054069

PRIDE project URI

• PRIDE
  1. PXD054069
     1. Label: PRIDE project
     2. Name: LC/MS Analysis of Phosphorylated Protein Changes in Mouse Brain Tissue After LPS Treatment and Angong Niuhuang Wan Administration