PXD053990
PXD053990 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Suppression of autophagy alters the proteome of the epidermal stratum corneum |
| Description | The stratum corneum of the epidermis consists of keratinocytes that have undergone a massive remodeling of intracellular structures. Autophagy is one of the mechanisms implicated in the breakdown of organelles and other components during cornification of keratinocytes. This mode of degradation is mediated by the enclosure of intracellular material by vesicles, known as autophagosomes, and the fusion of these vesicles with lysosomes, thereby exposing the targets of autophagy to proteases and other hydrolytic enzymes. The keratinocyte-specific deletion of autophagy-related gene 7 (Atg7) in mice and mass-spectrometry-based proteomic analysis of nails and hair demonstrated that autophagy degrades a wide range of proteins in keratinocytes that differentiate into hard skin appendages (Jaeger et al. 2019; Sukseree et al. 2024). Autophagy was also suggested to contribute to the degradation of the nucleus during epidermal cornification, and impairment of autophagy was implicated in the pathogenesis of psoriasis (Akinduro et al. 2016). However, the roles of autophagy in reshaping the proteome of epidermal keratinocytes during stratum corneum formation has not been reported so far. |
| HostingRepository | MassIVE |
| AnnounceDate | 2024-07-16 |
| AnnouncementXML | Submission_2024-07-16_15:28:20.158.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Brett Phinney |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Carbamidomethyl; Oxidation |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-07-16 15:02:00 | ID requested | |
| ⏵ 1 | 2024-07-16 15:28:20 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: autophagy, epidermis |
Contact List
| Leopold Eckhar | |
|---|---|
| contact affiliation | Department of Dermatology, Medical University of Vienna, Vienna |
| contact email | leopold.eckhart@meduniwien.ac.at |
| lab head | |
| Brett Phinney | |
| contact affiliation | UC Davis |
| contact email | brettsp@ucdavis.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v08/MSV000095353/ |
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